No association between catechol-O-methyltransferase polymorphisms and neurotic disorders among mainland Chinese university students.
ABSTRACT This study investigates the genetic association between COMT gene polymorphisms and neurotic disorders. Data were gotten from a case-control association study of 255 undergraduates affected by neurotic disorders and 269 matched healthy undergraduate controls. The polymorphisms of eight tag SNPs on COMT gene were tested using PCR-based Ligase Detection Reaction (PCR-LDR). The eight tag SNPs on COMT gene assessed were not associated with neurotic disorders. Our finding suggests that COMT gene may not be a susceptible gene for neurotic disorders.