Article

No association between catechol-O-methyltransferase polymorphisms and neurotic disorders among mainland Chinese university students.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China; Department of Psychiatry, University of Saskatchewan, Saskatoon, SK, Canada.
Psychiatry Research (impact factor: 2.52). 03/2012; DOI:10.1016/j.psychres.2011.10.020
Source: PubMed

ABSTRACT This study investigates the genetic association between COMT gene polymorphisms and neurotic disorders. Data were gotten from a case-control association study of 255 undergraduates affected by neurotic disorders and 269 matched healthy undergraduate controls. The polymorphisms of eight tag SNPs on COMT gene were tested using PCR-based Ligase Detection Reaction (PCR-LDR). The eight tag SNPs on COMT gene assessed were not associated with neurotic disorders. Our finding suggests that COMT gene may not be a susceptible gene for neurotic disorders.

0 0
 · 
0 Bookmarks
 · 
32 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

255 undergraduates
 
case-control association study
 
COMT gene
 
COMT gene polymorphisms
 
eight tag SNPs
 
genetic association
 
healthy undergraduate controls
 
neurotic disorders
 
PCR-based Ligase Detection Reaction
 
susceptible gene
 
tag SNPs
 

Changgui Kou