Article

Tissue Factor encryption and decryption: Facts and controversies

Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA.
Thrombosis Research (Impact Factor: 2.43). 03/2012; 129 Suppl 2:S13-7. DOI: 10.1016/j.thromres.2012.02.021
Source: PubMed

ABSTRACT Tissue factor (TF)-initiated coagulation plays a critical role in both hemostasis and thrombosis. It is generally believed that most of the tissue factor expressed on cell surfaces is maintained in a cryptic, i.e., coagulantly inactive state and an activation step (decryption) is required for the expression of maximum TF procoagulant activity. However, what exactly constitutes cryptic or procoagulant TF, molecular differences between these two forms and mechanisms that are responsible for transformation from one to the other form are not entirely clear and remain highly controversial, thus are a matter of ongoing debate. This brief review discusses pertinent literature on TF encryption/decryption with specific emphasis on the role of membrane phospholipids and reduction/oxidation of the TF Cys186-Cys209 disulfide bond in regulating TF activity at cell surfaces.

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Available from: Hema Kothari, Jul 07, 2015
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    • "This complex is able to activate FX, which in turn results in thrombin, which is responsible for thrombus stabilization (Monroe et al., 2002). Moreover, membrane-embedded TF is usually in inactive coagulant state (cryptic) while it requires activation to reach its full potency (decryption) (Rao et al., 2012). However, the mechanism behind the activation of circulating TF is not yet elucidated and such information would provide a significant breakthrough in the understanding of in vivo thrombosis. "
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