Article

Tissue factor encryption and decryption: facts and controversies.

Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, USA.
Thrombosis Research (impact factor: 2.44). 03/2012; 129 Suppl 2:S13-7. DOI:10.1016/j.thromres.2012.02.021 pp.S13-7
Source: PubMed

ABSTRACT Tissue factor (TF)-initiated coagulation plays a critical role in both hemostasis and thrombosis. It is generally believed that most of the tissue factor expressed on cell surfaces is maintained in a cryptic, i.e., coagulantly inactive state and an activation step (decryption) is required for the expression of maximum TF procoagulant activity. However, what exactly constitutes cryptic or procoagulant TF, molecular differences between these two forms and mechanisms that are responsible for transformation from one to the other form are not entirely clear and remain highly controversial, thus are a matter of ongoing debate. This brief review discusses pertinent literature on TF encryption/decryption with specific emphasis on the role of membrane phospholipids and reduction/oxidation of the TF Cys186-Cys209 disulfide bond in regulating TF activity at cell surfaces.

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Keywords

activation step
 
brief review discusses pertinent literature
 
cell surfaces
 
coagulantly inactive state
 
constitutes cryptic
 
cryptic
 
maximum TF procoagulant activity
 
membrane phospholipids
 
molecular differences
 
ongoing debate
 
procoagulant TF
 
regulating TF activity
 
responsible
 
specific emphasis
 
TF Cys186-Cys209 disulfide bond
 
TF)-initiated coagulation
 
tissue factor