Antidiarrhoeal Activity of Leaf Extract of Moringa Oleifera in Experimentally Induced Diarrhoea in Rats

International Journal of Phytomedicine 01/2011;


To evalauate the antidiarrhoeal activ ity of the hydroalcoholic extract of
moringa oleifera leaves. The hydroalc hoholic extract was evaluated using
rodent animal m odels of diarrhoea like the castor oil and ma gnesium sulfate
induced gastrointestinal motility, in a model of enteropoo ling induced by the
admi nistration of castor oil and PGE2, Charcoal meal test. Acute toxi city
and phytochemi cal constituents were also been evaluated using standardized
methods. The results of the present study indicates that the hydroalcoholic
extract of moringa oleifera leaves wa s effective in inducing a significant
protection against experime ntally induced diarrhoea by castor oil and
magnesium sulfate, as evidenced by a decrease in the numb er of frequency,
weight of stools after 4 hours with respect to control. The extract also
prevented the enteropooling induced by cas tor oil and PGE2 at all the doses
tested. Acute toxicity s tudies indic ated that the extract is saf e till 2500
mg/kg. The antidiarrhoeal activity though, not ascribed to any particular
phytochemi cal present, general tests performed indicated the presence of
flavonoids, tannis which were reported to produce antidiarrhoeal activity.
These results showed that Moringa ol eifera leaves posse ss anti-diarrheal
properties mediated through inhibition of hyper secretion and
gastrointe stinal mo tility that substantiate its use in the treatm ent of diarrhea
in traditiona l me dicines or folklore us e.

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Available from: Lakshmi Narayana Manjunath, Oct 10, 2015
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    ABSTRACT: Diarrhoea is a common disease which causes pain and may be deadly, especially in developing countries. In Bangladesh, diarrhoeal diseases affect thousands of people every year, and children are especially vulnerable. Bacterial toxins or viral infections are the most common cause of the disease. The diarrhoea outbreaks are often associated with flood affected areas with contaminated drinking water and an increased risk of spreading the water-borne disease. Not surprisingly, plants found in the near surroundings have been taken into use by the local community as medicine to treat diarrhoeal symptoms. These plants are cheaper and more easily available than conventional medicine. Our question is: What is the level of documentation supporting the use of these plants against diarrhoea and is their consumption safe? Do any of these plants have potential for further exploration? In this review, we have choosen seven plant species that are used in the treatment of diarrhoea; Diospyros peregrina, Heritiera littoralis, Ixora coccinea, Pongamia pinnata, Rhizophora mucronata, Xylocarpus granatum, and Xylocarpus moluccensis. Appearance and geographical distribution, traditional uses, chemical composition, and biological studies related to antidiarrhoeal activity will be presented. This review reveals that there is limited scientific evidence supporting the traditional use of these plants. Most promising are the barks from D. peregrina, X. granatum and X. moluccensis which contain tannins and have shown promising results in antidiarrhoeal mice models. The leaves of P. pinnata also show potential. We suggest these plants should be exploited further as possible traditional herbal remedies against diarrhoea including studies on efficacy, optimal dosage and safety.
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    ABSTRACT: The objective of present study was to evaluate in vivo anti-diarrheal potential of Moringa oleifera leaves. Sample was analyzed for quantative estimation of phytochemicals and anti-diarrheal activity of ethanol extract, at 150 and 300 mg/kg body weight (b.w) was investigated using castor oil induced model. Study reveals that protein was maximum in leaves (23.35%) followed by fiber, starch, oil, sugar, alkaloid, tannin, flavanoid and phenolic. At dosages of 150 and 300 mg/kg b.w extract showed significant (p<0.01) activity, as compared to control. In course of observation for 4 hr, oral dose of 300mg/kg b.w showed remarkable dose dependent delay in onset of copious diarrhoea, decrease in the frequency of purging, weight of wet stools, weight of total stool and percentage protection. Study, thus signifies the potential clinical effect of extract in disease and needs to be extended further for activity guided extraction/isolation of the active chemical moiety.