The virtual physiological human: challenges and opportunities.
ABSTRACT This paper summarises the current achievements and future developments of the virtual physiological human (VPH) technology. The VPH is an organised collection of computational frameworks and ICT-based tools for the multilevel modelling and simulation of the human anatomy and physiology. Once sufficiently developed, the VPH will provide an essential technological infrastructure to the Physiome Project, to pathology-specific initiatives in translational research, and to vertical solutions for the biomedical industry
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ABSTRACT: There are many virtual and constructive training systems that simulate injuries as well as degrading and improving patient conditions. Most of these systems use simplistic models to mimic the physiological response to the injuries and the response to treatment. For example, when modeling bleeding from a gunshot wound, many of the models are simply based on the amount of blood loss over time. An arbitrary time limit is often established to indicate a failure to save the patient. Little to no consideration is given to the munitions type or to the baseline physiology of the individual who is shot. Also, most of these games and simulations independently reinvent the math models and the physical models of these wounds. Proprietary nature of these diverse simulation platforms results in very little reuse. This effort will explore how physiology is being represented in several simulation platforms. Targeted virtual and constructive systems include: Pulse, STTC's Tactical Combat Casualty Care (TC3) game, STTC's!Forterra's OLIVE environment, and PEOSTRI's One Semi·Automated Force (OneSAF). Targeted mannequins include METI's Human Patient Simulators, Laerdals SimMan and Gaumards simulators. An analysis will be done on the level of fidelity currently included in each of these systems and on the pros and cons of how the physiological and the pharmacological responses are simulated. The analysis will also include a discussion on simulating versus replicating human physiology.
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ABSTRACT: The investigation of the behaviour of complex numerically simulated systems in response to key control parameters is an important topic in e-Science. One method of investigating such systems is via computational steering, where a scientist or group of scientists changes (steers) the value of control parameters as the simulation is evolving. If such simulations are run over multiple sessions they create complex data structures which can be described as steering \trees". In this paper we investigate a proposed method for reducing the cost of managing steering trees and describe a reference model simulation which oers the potential of comparing the eciency of dierent methods of managing such steering trees.
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ABSTRACT: This deliverable starts with a brief review of the projects that have been identified as background for the VPH framework. It then presents the methodology adopted for the elicitation of user S&P requirements by considering several categories of users intended as VPH stakeholders, the composition of a respondent sample of organisations, and the data collection methods. Consultation of stakeholders has been carried out by means of questionnaires of three different types: (i) a first pilot questionnaire (for identifying some main S&P topics), (ii) a full Web questionnaire for massive access (for statistics purposes), and (iii) a legal questionnaire (for contacting EU national data protection authorities). In addition to this, requirements have been elicited through interviews based on an interview guide) and in panel sessions in two workshops organised by RADICAL project.01/2010; Menevidis.