ReLiBase - An Object-Oriented Comprehensive Receptor/Ligand Database.
Article: [Protein structure and function].Nordisk medicin 11/1970; 84(47):1481-7.
Article: Protein folds and functions[Show abstract] [Hide abstract]
ABSTRACT: The recent rapid increase in the number of available three-dimensional protein structures has further highlighted the necessity to understand the relationship between biological function and structure. Using structural classification schemes such as SCOP, CATH and DALI, it is now possible to explore global relationships between protein fold and function, something which was previously impractical. Using a relational database of CATH data we have generated fold distributions for arbitrary selections of proteins automatically. These distributions have been examined in the light of protein function and bound ligand. Different enzyme classes are not clearly reflected in distributions of protein class and architecture, whereas the type of bound ligand has a much more dramatic effect. The availability of structural classification data has enabled this novel overview analysis. We conclude that function at the top level of the EC number enzyme classification is not related to fold, as only a very few specific residues are actually responsible for enzyme activity. Conversely, the fold is much more closely related to ligand type.Structure 08/1998; 6(7):875-84. DOI:10.1016/S0969-2126(98)00089-6 · 6.79 Impact Factor
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ABSTRACT: The design of an unprecedented multicomponent reaction to and synthesis of 2-amino-5-ketoaryl pyrroles are described. The compounds (14 examples) can be synthesized by reacting aminoacetophenone sulfonamides, (hetero)aromatic aldehydes, and malonodinitrile or cyanoacetic acid derivatives in one-pot manner. Pharmacophore features and potential applications of this new scaffold are discussed.Chemical Biology & Drug Design 03/2010; 75(3):277-83. DOI:10.1111/j.1747-0285.2009.00942.x · 2.51 Impact Factor