The study on the relationship between inflammatory factors and cardiac function based on chronic myocardial ischemia (syndrome of blood stasis model).
ABSTRACT To inquire into the change of the concentration of inflammatory factors (TNF- α, WBC, IL-1, IL-6, IL-8, IL-10) in blood plasma of miniature pigs with chronic myocardial ischemia, which was the syndrome of blood stasis model. The accompanying cardiac function also be investigated, relationship between them are analysed. Miniature pigs were divided into either Ameriod constrictor placement surgery group or sham operation group randomly, Syndromes associated physical and chemical indexes were measured at 4 and 8 weeks after surgery. At 4 weeks, Chinese herbs based on diagnostic differentiations were given to model group, Compared with sham operation group, The concentration of CRP, IL-1, IL-6, IL-8, IL-10 and TNF- α in model group all obviously changed, EF FS changed obviously, which decreased by 37.66% and 38.16% respectively, systolic thickness of left ventricular anterior wall turned thicker to 55.32% compared with sham, and the express of TNF-α and EDV, ESV presented negative correlation, with the deteriorate of cardiac function, it increased. Compounds can improve the pathological changes by reducing the inflammatory response, but the TNF-α cannot be down-regulated by the compound. We can conclude that in earlier stage of the Syndrome of blood stasis, inflammatory cytokines especially TNF-α play a vital role that contribute the pathology mechanism, TNF-α which has a positive correlation with cardiac function, can be used as indicators of inflammatory activation and can reflect the state of cardiac function. Current data indicate that plasma levels of inflammatory markers especially TNF-α may have clinical utility in helping identify and cure individuals at high risk for future blood stasis syndrome.