[show abstract][hide abstract] ABSTRACT: The programmability and the integration of biochemical processing protocols are addressed for DNA computing using photochemical and microsystem techniques. A magnetically switchable selective transfer module (STM) is presented which implements the basic sequence-specific DNA filtering operation under constant flow. Secondly, a single steady flow system of STMs is presented which solves an arbitrary instance of the maximal clique problem of given maximum size N. Values of N up to about 100 should be achievable with current lithographic techniques. The specific problem is encoded in an initial labeling pattern of each module with one of 2N DNA oligonucleotides, identical for all instances of maximal clique. Thirdly, a method for optically programming the DNA labeling process via photochemical lithography is proposed, allowing different problem instances to be specified. No hydrodynamic switching of flows is required during operation -- the STMs are synchronously clocked by an external magnet. An experimental implementation of this architecture is under construction and will be reported elsewhere.
[show abstract][hide abstract] ABSTRACT: DNA computing, or, more generally, molecular computing, is an exciting fast developing interdisciplinary area. Research in this area concerns theory, experiments, and applications of DNA computing. In this paper, we demonstrate the theoretical developments by discussing a number of selected topics. We also give an introduction to the basic structure of DNA and the basic DNA processing tools.
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