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    ABSTRACT: The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data. GEO provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-throughput gene expression and genomic hybridization experiments. GEO is not intended to replace in house gene expression databases that benefit from coherent data sets, and which are constructed to facilitate a particular analytic method, but rather complement these by acting as a tertiary, central data distribution hub. The three central data entities of GEO are platforms, samples and series, and were designed with gene expression and genomic hybridization experiments in mind. A platform is, essentially, a list of probes that define what set of molecules may be detected. A sample describes the set of molecules that are being probed and references a single platform used to generate its molecular abundance data. A series organizes samples into the meaningful data sets which make up an experiment. The GEO repository is publicly accessible through the World Wide Web at http://www.ncbi.nlm.nih.gov/geo.
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    ABSTRACT: OGSA-DQP is a distributed query processor exposed to users as an Open Grid Services Architecture (OGSA)-compliant Grid service. This service supports the compilation and evaluation of queries that combine data obtained from multiple services on the Grid, including Grid Database Services (GDSs) and computational web services. Not only does OGSA-DQP support integrated access to multiple Grid services, it is itself implemented as a collection of interacting Grid services. OGSA-DQP illustrates how Grid service orchestrations can be used to perform complex, data-intensive parallel computations. The OGSA-DQP prototype is downloadable from www.ogsadai.org.uk/dqp/. This demonstration aims to illustrate the capabilities of OGSA-DQP prototype via a GUI Client over a collection of bioinformatics databases and analysis tools.
    Advances in Database Technology - EDBT 2004, 9th International Conference on Extending Database Technology, Heraklion, Crete, Greece, March 14-18, 2004, Proceedings; 01/2004
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    ABSTRACT: Biomedicine has experienced explosive growth, fueled in parts by the substantial increase of government support, continued development of the biotechnology industry, and the increasing adoption of molecular-based medicine. At its core, it is composed of fiercely independent, innovative, entrepreneurial individuals, organizations, and institutions. The field has developed unprecedented capacity to characterize biologic systems at their most fundamental levels with the use of tools and technologies almost unimaginable a generation ago. Biomedicine is at the precipice of unlocking the very essence of biologic life and enabling a new generation of medicine. Development and deployment of cyberinfrastructure may prove to be on the critical path to obtaining these goals.
    Science 06/2005; 308(5723):821-4. · 31.20 Impact Factor

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May 23, 2014