Article

Reduced plasma renin activity in essential hypertension: effects of blood pressure, age and sodium.

Clinical science and molecular medicine. Supplement 01/1977; 3:185s-188s. pp.185s-188s
Source: PubMed

ABSTRACT 1. Supine plasma renin activity and its responsiveness to erect posture and frusemide were reduced in fifty-one patients with essential hypertension, compared with fifty-one age- and sex-matched control subjects. 2. Twenty-four hour urinary sodium excretion was similar in hypertensive patients nad control subjects. 2. Twenty-four hour urinary sodium excretion was similar in hypertensive patients and control subjects, but after intravenous frusemide hypertensive patients excreted significantly less sodium. 3. A significant inverse relationship between plasma renin activity and diastolic blood pressure was demonstrated in hypertensive patients and in normotensive control subjects. 4. A significant inverse relationship between plasma renin activity and age, independent of blood pressure, was shown in hypertensive patients and control subjects. 5. It is concluded that the reduced renin values found in essential hypertension are, in part, the result of the elevated blood pressure acting on the kidney.

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    Article: Factors determining direct arterial pressure and its variability in hypertensive man.
    R D Watson, T J Stallard, R M Flinn, W A Littler
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    ABSTRACT: Intra-arterial pressure was recorded continuously in 26 patients with uncomplicated essential hypertension under standardized conditions. Recordings were analyzed beat by beat to obtain mean pressures and variability, expressed as the standard deviation of the frequency histogram. The major factors influencing variability were the level of pressure and the intensity of physical activity; systolic variability increased with progressive impairment of sino-aortic baroreflexes. Diastolic pressure increased with the level of sympathetic activity as reflected by plasma norepinephrine levels. After allowance for the decrease of plasma renin activity (PRA) with age, direct relationships were observed between PRA (log values) and the level of pressure and systolic variability; plasma angiotensin II values did not correlate. Systolic variability increased with the systolic response to cold but was unrelated to the response to dynamic or isometric exercise. Variability also tended to increase with obesity and was unrelated to age, sex, or race.
    Hypertension 2(3):333-41. · 6.21 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

blood pressure
 
control subjects
 
diastolic blood pressure
 
elevated blood pressure
 
frusemide
 
hypertensive patients
 
hypertensive patients nad control subjects
 
intravenous frusemide hypertensive patients excreted
 
kidney
 
normotensive control subjects
 
patients
 
plasma renin activity
 
sex-matched control subjects
 
significant inverse relationship
 
Supine plasma renin activity
 
Twenty-four hour urinary sodium excretion
 

G W Thomas