Micro RNA: New aspect in pathobiology of preeclampsia?

Egyptian Journal of Medical Human Genetics 02/2012; DOI: 10.1016/j.ejmhg.2011.09.002


The discovery of miRNA in 1993, by Ambros et al. has had a huge influence in pathogenesis theory; diagnosis and treatment approach to some diseases. Some scientifically proven theories have been proposed to seek the association of alterations of miRNA expression to incidences and severity of preeclampsia (PE). In this review we explore the result of such investigations that discuss the association of miRNA and PE along with the role of various mRNAs in PE pathogenesis.

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Available from: Harapan Harapan, MD,
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    • "Abnormalities can occur by the following ways: (1) loss or downregulation of miRNA expression due to mutation, epigenetic inactivation, transcriptional downregulation or abnormality processing [48], (2) overexpression of miRNA due to gene amplification or transcriptional upregulation may result in the suppressed production of its target proteins [49], (3) a mutation in 3 0 UTR of an mRNA may affect a miRNA binding site and the miRNA may no longer be able to bind [50], and (4) a mutation in 3 0 UTR of a gene may generate a new miRNA binding site. [51] A huge number of studies reported that miRNAs dysregulation associated to a wide spectrum of diseases such as chronic kidney disease [9], liver cirrhosis [14], systemic sclerosis [15], cardiac fibrosis [13], diabetes [11], pregnancy-related diseases [10] [52], and most notably cancer [12]. Recent studies have shown the regulation of miRNA in human diseases only understood and explained by genetic (deletions , mutations and translocation), epigenetic mechanisms (methylation) or abnormalities in the miRNA processing machinery . "
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    ABSTRACT: Preeclampsia, “the disease of theory”, is a major cause of maternal mortality and morbidities, perinatal deaths, preterm birth, and intrauterine growth restriction. Several pathophysiological mechanisms have been proposed in the development of preeclampsia, including endothelial dysfunction, an inflammatory pathway, oxidative stress, activation of thrombosis, the renin-angiotensin system and angiogenic factors contribute in pathogenesis of preeclampsia. However, the individual theory cannot explain preeclampsia in holistically setting. The discovery of MicroRNA in 1993 has had a huge influence in pathogenesis theory; diagnosis and treatment approach to some diseases. Albeit only 1% of the genomic transcripts, it has been estimated that miRNAs regulate ~30% of human genes. This book discusses the roles of MicroRNA in several pathophysiological mechanisms have been proposed in the development of preeclampsia in advance setting. This book, clearly, shows the role of MicroRNA as a new aspect in pathobiology of preeclampsia. This book helps people to understanding more about preeclampsia from advance stand point.
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