Micro RNA: New aspect in pathobiology of preeclampsia?

Egyptian Journal of Medical Human Genetics 02/2012; DOI: 10.1016/j.ejmhg.2011.09.002

ABSTRACT The discovery of miRNA in 1993, by Ambros et al. has had a huge influence in pathogenesis theory; diagnosis and treatment approach to some diseases. Some scientifically proven theories have been proposed to seek the association of alterations of miRNA expression to incidences and severity of preeclampsia (PE). In this review we explore the result of such investigations that discuss the association of miRNA and PE along with the role of various mRNAs in PE pathogenesis.

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    ABSTRACT: Preeclampsia, “the disease of theory”, is a major cause of maternal mortality and morbidities, perinatal deaths, preterm birth, and intrauterine growth restriction. Several pathophysiological mechanisms have been proposed in the development of preeclampsia, including endothelial dysfunction, an inflammatory pathway, oxidative stress, activation of thrombosis, the renin-angiotensin system and angiogenic factors contribute in pathogenesis of preeclampsia. However, the individual theory cannot explain preeclampsia in holistically setting. The discovery of MicroRNA in 1993 has had a huge influence in pathogenesis theory; diagnosis and treatment approach to some diseases. Albeit only 1% of the genomic transcripts, it has been estimated that miRNAs regulate ~30% of human genes. This book discusses the roles of MicroRNA in several pathophysiological mechanisms have been proposed in the development of preeclampsia in advance setting. This book, clearly, shows the role of MicroRNA as a new aspect in pathobiology of preeclampsia. This book helps people to understanding more about preeclampsia from advance stand point.
    1st Edition 01/2012; LAP Lambert Academic Publishing., ISBN: 978-3-659-28513-4
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    ABSTRACT: The central proteins for protection against tuberculosis are attributed to interferon-γ, tumor necrosis factor-α, interleukin (IL)-6 and IL-1β, while IL-10 primarily suppresses anti-mycobacterial responses. Several studies found alteration of expression profile of genes involved in anti-mycobacterial responses in macrophages and natural killer (NK) cells from active and latent tuberculosis and from tuberculosis and healthy controls. This alteration of cellular composition might be regulated by microRNAs (miRNAs). Albeit only 1% of the genomic transcripts in mammalian cells encode miRNA, they are predicted to control the activity of more than 60% of all protein-coding genes and they have a huge influence in pathogenesis theory, diagnosis and treatment approach to some diseases. Several miRNAs have been found to regulate T cell differentiation and function and have critical role in regulating the innate function of macrophages, dendritic cells and NK cells. Here, we have reviewed the role of miRNAs implicated in tuberculosis infection, especially related to their new roles in the molecular pathology of tuberculosis immunology and as new targets for future tuberculosis diagnostics.
    Tuberculosis (Edinburgh, Scotland) 08/2013; DOI:10.1016/ · 3.50 Impact Factor


Available from
May 29, 2014