Alpha-methyldopa-induced immune thrombocytopenia. Report of case.

American Journal of Clinical Pathology (Impact Factor: 2.51). 08/1975; 64(1):113-5.
Source: PubMed


The clinical and laboratory features of a case of alphamethyldopa-induced thrombocytopenia are described. This is the second reported case in which the presence of alpha-methyldopa-induced platelet antibodies have been demonstrated.

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  • Pharmacology [?] Therapeutics 02/1979; 7(1):153-72. DOI:10.1016/0163-7258(79)90028-7 · 9.72 Impact Factor
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    ABSTRACT: An inhibitor to the plasma coagulation factor VIII and abnormally high levels of platelet associated IgG (PAIgG) were found in a patient whilst on methyldopa. Both these parameters fell on initial withdrawal, but on rechallenge with the drug only the PAIgG rose to the high presenting levels. No inhibitory activity to factor VIIIc could be detected in a concentrated eluate prepared from the patient's platelets. These results may imply that two distinct antibodies were provoked by the administration of methyldopa, but could also be explained by the action of anti VIIIc alone on the patient's platelets.
    British Journal of Haematology 08/1983; 54(3):485-8. DOI:10.1111/j.1365-2141.1983.tb02123.x · 4.71 Impact Factor
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    ABSTRACT: Platelet function was analyzed in two hypothyroid patients who were taking methyldopa. Results from these two patients are compared to those obtained in seven others with hypothyroidism on no medications. Bleeding times in the two drug patients were 33 and 26 minutes compared to normal values (4.0 to 8.0 minutes) in the other hypothyroid individuals. In addition, platelet aggregation responses to epinephrine, collagen, and ristocetin were abnormal in these two patients; these were normal in the others with hypothyroidism. Repeat studies were done in the first drug patient when she was euthyroid and still receiving methyldopa. Her bleeding time decreased to 11 minutes, platelet retention increased from 31% to 75%, and abnormal aggregation responses corrected to normal. Factor VIII coagulant activity, VIII antigenic activity, VIII ristocetin cofactor activity, and two-dimensional immunoelectrophoresis of VIII antigen were normal. These findings suggest that methyldopa can potentiate the mild platelet function defect seen in patients with hypothyroidism.
    American Journal of Hematology 09/1984; 17(2):209-15. DOI:10.1002/ajh.2830170213 · 3.80 Impact Factor
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