Albinism in Nigeria. A clinical and social study.
ABSTRACT A study of 1000 Nigerian albinos, all of Negro stock, showed various types of albinism with their different modes of transmission--oculocutaneous, ocular and cutaneous. The much higher incidence among the more settled communities in the south, compared with the more nomadic communities in the north, may be related to greater inbreeding tendencies in the south. The sun and society are hostile to the albinos. Under the tropical sunshine, their melanin-deficient skin develops wrinkles, lentigines, actinic keratoses and epitheliomata from which they may die in early adult life or in middle age. Myopia and other ocular defects retard the progress of many albinos in school and they eventually drop out to seek disastrous menial outdoor occupations. Registering albinos early in life, assuring their families that albino defects are confined to the skin and eyes, advising on protective clothing and sun-screening agents, correcting myopia, assisting with indooor occupations, and early treatment of actinic keratoses and skin cancer should help many albinos to attain social acceptance and a ripe old age.
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ABSTRACT: Forty-three cases of melanoma occurring before age 20 years were reviewed from a twenty-one year period at a single center. Thirteen of the patients were preadolescent children, and 90% were Caucasian. Histologic review of 39 available primary tumors showed superficial spreading and nodular types only. Thickness ranged from 0.23 mm to 5.43 mm, with a mean of 1.58 mm. Ulceration was present in 8%, necrosis in 28%, evidence of regression in 21%, and antecdent nevus in 33% of cases. The overall 5 year survival is 79%, with a median follow-up of 42 months. There is no detectable survival difference between preadolescent children and adolescents. Several treatment failures occurred after improper bisopy and/or inaccurate original diagnosis of Spitz's nevus. Of 34 Stage I and II patients give definitive surgical treatment by the authors, the 5 year survival is 95%. Although histologic confusion with Spitz's nevi occasionally occurs, melanoma in this age group can be treated with good results. (js)
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ABSTRACT: Ten cases of advanced squamous cell carcinoma of the skin in albinos, treated by radiotherapy from 1973 to 1979 at the Muhimbili Medical Center of Dar-es-Salaam, have been reviewed. Age, sex, duration of symptoms, anatomic distribution, stage of disease, and treatment are reviewed. The relationship between albinism, sunlight, and skin cancer is discussed and a practical program of prevention is suggested. Advanced carcinoma of skin in albinos may be managed successfully with judicious radiation therapy. Excellent objective responses have been noted. No assessment of long-term control is made due to poor follow-up of patients.Journal of the National Medical Association 12/1981; 73(11):1047-54.
Article: The Albino Fellowship.International Journal of Dermatology 04/1982; 21(2):84-5. DOI:10.1111/j.1365-4362.1982.tb00505.x