Aromatic amines can be detected in the nanomole range with the reagent Fluram, with which they form stable yellow derivatives. Fluram in glacial acetic acid reacts only with aromatic amines. The reaction is complete in 10 minutes and can be performed on thin-layer (TLC) chromatograms making possible the specific measurement of aromatic amines. The yellow product can be quantitatively eluted from the TLC plates. Fluram is colorless, and the blanks are zero.
[Show abstract][Hide abstract] ABSTRACT: A procedure has been developed for the isolation and determination of the coccidiostat arprinocid and its metabolites in tissue. Analysis can be performed with a sensitivity of 0.04 ppm using a combined gas chromatographic-mass spectroscopic detection system. Recoveries of arprinocid spikes average 76% for liver, kidney, and muscle and 70% for skin/fat.
Journal of Agricultural and Food Chemistry 07/1979; 27(4):753-6. DOI:10.1021/jf60224a001 · 2.91 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The aerosol fraction of the oxidative thermal decomposition products (700 degrees C) of rigid polyurethane foam was collected on glass fiber filters and fractionated into either-soluble neutral, acidic, and basic fractions and water-soluble compounds. The fractions showed mutagenic activity in a bacterial fluctuation test with Salmonella typhimurium TA98 or Escherichia coli CM891 as the tester strains. All the fractions induced mutations in both strains after metabolic activation with rat liver S-9 mix. The basic and the water-soluble fractions were mutagenic for S. typhimurium TA 98 even without activation. Thin-layer chromatography showed the presence of several primary aromatic amines in the aerosol. Polycyclic aromatic hydrocarbons were not detected by glass capillary gas chromatogaphy.
International Archives of Occupational and Environmental Health 02/1980; 47(1):47-52. DOI:10.1007/BF00378327 · 2.20 Impact Factor
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