Article

Central motor conduction to upper and lower limbs after magnetic stimulation of the brain and peripheral nerve abnormalities in 20 patients with Friedreich's ataxia.

Electromiography Department, Hospital La Paz, Madrid, Spain.
Acta Neurologica Scandinavica (impact factor: 2.47). 06/1992; 85(5):323-6. pp.323-6
Source: PubMed

ABSTRACT Central motor conduction time (CMCT) to thenar and soleus muscles was measured after magnetic stimulation of the cortex in 20 cases of Friedreich's ataxia (FA) and was abnormal in all. CMCT values were related to disease duration and disability. The amplitude of CMAP after cortex stimulation was severely reduced in the most disabled patients. Reduction in amplitude of the nerve evoked potentials was related neither to disease duration nor grade of disability. These results suggest that clinical worsening in FA is mainly due to progressive central motor pathway involvement. CMCT study is a better index of disease progression than peripheral nerve examination. Abnormalities in CMCT may be the third electrophysiological diagnostic criterion in FA, after reduced amplitude of nerve action potentials and absent H reflex.

0 0
 · 
0 Bookmarks
 · 
13 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

Central motor conduction time
 
CMCT study
 
disabled patients
 
disease duration
 
disease progression
 
FA
 
Friedreich's ataxia
 
H reflex
 
magnetic stimulation
 
peripheral nerve examination
 
progressive central motor pathway involvement
 
soleus muscles
 
third electrophysiological diagnostic criterion
 

A Cruz Martínez