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Kapur S, Mann JJ. Role of the dopaminergic system in depression. Biol Psychiatry 32: 1-17

Department of Psychiatry, University of Pittsburgh School of Medicine, PA.
Biological Psychiatry (Impact Factor: 10.25). 08/1992; 32(1):1-17. DOI: 10.1016/0006-3223(92)90137-O
Source: PubMed

ABSTRACT A hypothesis implicating dopamine in depression was proposed over 15 years ago (Randrup et al 1975). The identification of multiple new subtypes of dopamine receptors and evolving views regarding the function of the dopamine systems in the brain require a reexamination of this hypothesis. Results from studies in depression, Parkinson's disease, and animal models of depression suggest a deficiency of dopamine in depression. Dopamine precursors, dopamine agonists, and dopamine reuptake inhibitors show therapeutic efficacy in depression. Electroconvulsive therapy (ECT) and standard pharmacological antidepressants enhance dopamine function. Studies using receptor-specific drugs in clinical trials and neuroimaging studies are needed to further clarify the role of dopamine in depression.

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    • "Indeed, the hypofunction of the mesolimbic dopaminergic pathway is responsible for anhedonia , one of the major symptoms of depression, which is scarcely affected by SSRI treatment (Kulkarni and Dhir, 2009; Willner, 1983). Worthy of note, homovanillic acid, the major metabolite of dopamine, is decreased in the cerebrospinal fluid of depressed patients (Brown and Gershon, 1993; Kapur and Mann, 1992). Different antidepressant drugs can affect dopaminergic neurotransmission: desipramine increases dopamine levels in the frontal "
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    European journal of pharmacology 07/2013; 719(1-3). DOI:10.1016/j.ejphar.2013.07.022 · 2.68 Impact Factor
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    • "The second factor is an alteration in participants’ ability to learn from reward feedback. This is emphasized by preclinical animal models of depression [19-22] and, because of the close association between dopamine (DA) signalling and reward learning [23-27], by neurobiological accounts linking anhedonia to DA [11,14,28-35]. It is most important to separate these factors, since they are likely to be associated with radically different ætiologies and therapeutic routes. "
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