Effect of exercise training on glomerular filtration rate of mice with various degrees of renal mass reduction.

Department of Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel.
American Journal of Nephrology (Impact Factor: 2.62). 02/1992; 12(3):174-8. DOI: 10.1159/000168441
Source: PubMed

ABSTRACT We studied the effect of repeated heavy physical activity on glomerular filtration rate (GFR) in healthy, uninephrectomized and experimentally uremic mice. Exercise consisted of running uphill in the inner surface of a rotating cylinder in ideal environmental temperature. In the control groups, no extra physical activity was imposed. In sham-operated and nephrectomized mice, GFR rose significantly following training. By contrast, GFR did not change significantly in the exercised mice with experimental renal failure 24 h following the last exercise session. During the same period, no significant change was observed in GFR of any of the control groups. Following training in each experimental group, mean aortic blood pressure as well as fractional kidney weight (kidney weight/body weight) were not different from the respective controls. Our results indicate that the capacity to augment GFR by physical training is dependent upon the amount of remaining functional renal tissue.

  • [Show abstract] [Hide abstract]
    ABSTRACT: Some lifestyle behaviors and obesity are risk factors for vascular disease, but their relation to kidney disease is uncertain. To determine whether physical inactivity, smoking, alcohol drinking and obesity are associated with the risk of chronic kidney disease, we examined data from a nonconcurrent cohort study of 9,082 U.S. adults, aged 30-74 years, who participated in the second National Health and Nutrition Examination Survey (NHANES II) from 1976 through 1980. By linking the NHANES II Mortality Study with the Medicare end-stage kidney disease registry, we identified 189 incident cases of either treated end-stage kidney disease or chronic kidney disease-related death through 1992. The risk of chronic kidney disease was related to physical inactivity both with and without adjustment for age, sex, race and body-mass index. The adjusted relative risk (RR) of moderately active versus very active persons was 1.2 (95% confidence interval = 0.7-1.8), and of inactive versus very active was 2.2 (1.3-3.8). Risk was also related to smoking; the RR in smokers of 1-20 cigarettes a day versus never smokers was 1.2 (0.7-2.3), and in smokers of more than 20 cigarettes a day, the RR was 2.3 (1.3-4.2). The RR in morbidly obese (body-mass index >/= 35 kg/m2) compared with normal weight persons was 2.3 (1.1-4.9), but risk was not increased for those classified as overweight or obese. Obesity risk appeared largely mediated by diabetes and hypertension, whereas physical inactivity risk was only partly explained by these factors, and smoking risk was independent of them. Alcohol consumption was not related to chronic kidney disease. These data suggest that physical inactivity, smoking and morbid obesity contribute to the risk of chronic kidney disease.
    Epidemiology 08/2003; 14(4):479-87. · 5.74 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Training alterations in elite cyclists may cause transient changes in glomerular filtration rate. To these authors' knowledge, no biochemical investigation of chronic renal function in athletes during a training cycle exists. The purpose of the present archival study was to evaluate the effects of training on homeostatic renal function, evaluated predicted glomerular filtration rate (GFR). Eight male competitive college cyclists (mean ± SD: age: 22.2 ± 3.8 yrs, height: 1.80 ± 0.06 m, mass: 76.6 ± 7.9 kg, and body fat was 7 ± 2%) volunteered to undergo 12 weeks of training, and were required to undergo blood sampling at timed intervals to calculate GFR. Homeostatic GFR was altered significantly during various points in the investigation. Volume and average cycling speed were found to have moderate correlations to alterations in GFR. In addition to these findings, 7 of the 8 subjects had GFR's below normal physiological ranges during some point in the experiment. The duration, intensity, and volume of cycling appear to have an influence on renal function. This influence is pronounced during periods when the athletes are unaccustomed to the training load.
    Journal of sports science & medicine 01/2004; · 0.89 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The possible beneficial effect of regular exercise training on the progression of chronic renal failure was studied in a prospective randomized controlled study. Thirty patients with a median glomerular filtration rate (GFR) of 25 ml/(min.1.73 m2) (range 10-43) were randomized to physical training (30 min of bicycling daily or an equal amount of other physical activities) or to maintenance of the usual lifestyle. The median maximal work capacity increased significantly in the exercise group and remained unchanged in the control group during a median observation time of 20 months whereas the rate of progression judged by the slope of GFR versus time plot was equal in the two groups. Hence, the beneficial effect of exercise training, earlier observed in rat studies, could not be reproduced in our patients. Physical exercise had no untoward effect on progression of renal disease.
    Nephron 02/1997; 75(1):36-40. · 13.26 Impact Factor