Effect of exercise training on glomerular filtration rate of mice with various degrees of renal mass reduction.

Department of Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel.
American Journal of Nephrology (Impact Factor: 2.67). 02/1992; 12(3):174-8. DOI: 10.1159/000168441
Source: PubMed

ABSTRACT We studied the effect of repeated heavy physical activity on glomerular filtration rate (GFR) in healthy, uninephrectomized and experimentally uremic mice. Exercise consisted of running uphill in the inner surface of a rotating cylinder in ideal environmental temperature. In the control groups, no extra physical activity was imposed. In sham-operated and nephrectomized mice, GFR rose significantly following training. By contrast, GFR did not change significantly in the exercised mice with experimental renal failure 24 h following the last exercise session. During the same period, no significant change was observed in GFR of any of the control groups. Following training in each experimental group, mean aortic blood pressure as well as fractional kidney weight (kidney weight/body weight) were not different from the respective controls. Our results indicate that the capacity to augment GFR by physical training is dependent upon the amount of remaining functional renal tissue.

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    • "The results of these studies suggest that low intensity, long duration exercise causes an increase in GFR following exercise. Conversely, Averbukh et al. (1992) did not support this trend in healthy mice. They noted that GFR did not alter significantly after training. "
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    ABSTRACT: Training alterations in elite cyclists may cause transient changes in glomerular filtration rate. To these authors' knowledge, no biochemical investigation of chronic renal function in athletes during a training cycle exists. The purpose of the present archival study was to evaluate the effects of training on homeostatic renal function, evaluated predicted glomerular filtration rate (GFR). Eight male competitive college cyclists (mean ± SD: age: 22.2 ± 3.8 yrs, height: 1.80 ± 0.06 m, mass: 76.6 ± 7.9 kg, and body fat was 7 ± 2%) volunteered to undergo 12 weeks of training, and were required to undergo blood sampling at timed intervals to calculate GFR. Homeostatic GFR was altered significantly during various points in the investigation. Volume and average cycling speed were found to have moderate correlations to alterations in GFR. In addition to these findings, 7 of the 8 subjects had GFR's below normal physiological ranges during some point in the experiment. The duration, intensity, and volume of cycling appear to have an influence on renal function. This influence is pronounced during periods when the athletes are unaccustomed to the training load.
    Journal of sports science & medicine 01/2004; 3(YISI 1). · 1.03 Impact Factor
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    • "Reduction of proteinuria is the most important goal of rehabilitation aimed at halting the progression of chronic nephropathy (Ruggenenti et al., 1998). Land-based exercise studies have shown no benefit on renal function, neither in clinical (Eidemak et al., 1997) nor in experimental (Averbukh et al., 1992; Bergamaschi et al., 1997) studies. In our study, proteinuria diminished significantly and the serum Cys-C decrease was reinforced by a small GFR improvement. "
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    ABSTRACT: The possible beneficial effect of regular aquatic exercise on cardiorespiratory, renal lipid parameters and oxidative stress status was studied in patients with mild to moderate renal failure. The exercise group did low-intensity aerobic exercise in the pool during a period of 12 weeks, twice a week, with sessions lasting for 30 min. Matched control participants remained sedentary. The results showed that in the exercise group all cardiorespiratory functional parameters improved and resting blood pressure lowered significantly. Proteinuria and cystatin-C were diminished significantly and glomerular filtration rate was enhanced. To evaluate the changes in oxidative stress status in the serum, products of lipid peroxidation (LPO) and serum glutathione values were measured. LPO was reduced significantly and reduced glutathione levels showed significant improvement after the exercise-conditioning programme. In the control group the data either remained the same or worsened in the same period of time. In conclusion, regular water-based exercise has beneficial effects on the cardiorespiratory, renal functional parameters and oxidative stress status in patients with moderate renal failure, and can be used in the complex rehabilitation of chronic renal failure patients, together with blood pressure control, dietary consultation, encouragement and education to prevent physical worsening and to postpone cardiovascular and renal atherosclerotic complications.
    International Journal of Rehabilitation Research 07/2003; 26(2):153-6. DOI:10.1097/01.mrr.0000070755.63544.5a · 1.28 Impact Factor
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    ABSTRACT: The possible beneficial effect of regular exercise training on the progression of chronic renal failure was studied in a prospective randomized controlled study. Thirty patients with a median glomerular filtration rate (GFR) of 25 ml/(min.1.73 m2) (range 10-43) were randomized to physical training (30 min of bicycling daily or an equal amount of other physical activities) or to maintenance of the usual lifestyle. The median maximal work capacity increased significantly in the exercise group and remained unchanged in the control group during a median observation time of 20 months whereas the rate of progression judged by the slope of GFR versus time plot was equal in the two groups. Hence, the beneficial effect of exercise training, earlier observed in rat studies, could not be reproduced in our patients. Physical exercise had no untoward effect on progression of renal disease.
    Nephron 02/1997; 75(1):36-40. DOI:10.1159/000189497 · 13.26 Impact Factor
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