Article

Cholesterol-lowering effects of calcium carbonate in patients with mild to moderate hypercholesterolemia.

Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 55415.
Archives of Internal Medicine (impact factor: 11.46). 01/1993; 152(12):2441-4.
Source: PubMed

ABSTRACT In recent years, several authors have noted that oral calcium treatment was associated with a reduction in serum cholesterol level.
Calcium carbonate was examined for its ability to lower serum cholesterol levels in hypercholesterolemic patients. Fifty-six patients with mild to moderate hypercholesterolemia were examined in this randomized, double-blind, placebo-controlled crossover study. Patients were treated with a low-fat, low-cholesterol diet targeted at the American Heart Association Step-1 diet for 8 weeks before and while receiving placebo or calcium carbonate (9.98 mmol [400 mg] of elemental calcium) three times daily with meals for 6 weeks. Patients were then crossed over to the alternate treatment for an additional 6-week period.
Compared with placebo, calcium carbonate achieved a 4.4% reduction in the low-density lipoprotein cholesterol level, and a 4.1% increase in the high-density lipoprotein cholesterol level. The ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol significantly decreased by 6.5% with calcium carbonate treatment. Calcium carbonate treatment did not significantly affect blood pressure or serum levels of triglycerides, lipoprotein Apo B, or calcium. Relative urinary saturation ratios of calcium oxalate levels were unchanged during calcium carbonate therapy. Compliance with diet and treatment was excellent and no significant adverse effects were noted.
Thus, calcium carbonate was a modestly effective and well-tolerated adjunct to diet in the management of mild to moderate hypercholesterolemia in this clinical study.

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Keywords

alternate treatment
 
Calcium carbonate
 
calcium carbonate therapy
 
calcium carbonate treatment
 
calcium oxalate levels
 
elemental calcium
 
high-density lipoprotein cholesterol
 
high-density lipoprotein cholesterol level
 
hypercholesterolemic patients
 
lipoprotein Apo B
 
low-density lipoprotein cholesterol
 
low-density lipoprotein cholesterol level
 
lower serum cholesterol levels
 
moderate hypercholesterolemia
 
oral calcium treatment
 
placebo-controlled crossover study
 
Relative urinary saturation ratios
 
serum cholesterol level
 
serum levels
 
significant adverse effects
 

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