Role of Vitamin E-acetate on Cisplatin induced genotoxicity: An in vivo analysis

Central European Journal of Biology (Impact Factor: 0.71). 04/2012; 7(2). DOI: 10.2478/s11535-012-0001-z


Vitamin E has generated immense interest because of its potential of being an antioxidant, a neuroprotector, and a protector against
atherosclerosis, carcinogenesis and cardiovascular disease. However, the prooxidant chemistry of Vitamin E cannot be ignored since
it is related to the generation of peroxyl radicals. In the present study, 125, 250 and 500 mg/kg of Vitamin E-acetate (VE) administered
intraperitoneally (i.p.) to Balb/C mice significantly induced 6.00%, 8.00% and 11.33% (control value=2.33%) of chromosome
aberrations (CA) and 0.88%, 1.39% and 1.81% (control value=0.61%) of micronucleus (MN), following 24 hour of treatment in
the bone marrow cells. In the germ cells, VE did not induce any sperm head abnormality (SHA) after 35 days of exposure. Most
importantly, it has been observed that pre-treatment with VE significantly reduces CA, MN, and SHA induction by chemotherapeutic
drug Cisplatin (CIS). Our findings suggest that lone treatment with VE induce genotoxicity in somatic cells after 24 and 48 hours of
exposure but not in germ cells after 35 days of exposure, whereas pre-treatment with VE reduces CIS induced genotoxicity as well
as cytotoxicity. There exists a thin line of difference on the behavioral transition of VE when acting alone and when acting with a drug.

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