Antihyperlipidemic Effect of Ethanolic Extract of Hibiscus rosa sinensis Flowers in Hyperlipidemic Rats

RGUHS Journal of Pharmaceutical Sciences 01/2011; 1:117-122.

ABSTRACT The antihyperlipidemic activity of Hibiscus rosa sinensis flowers ethanolic extract was investigated in triton (400 mg/kg b.w.) induced and
atherogenic diet-induced hyperlipidemic rats in comparison of a known antihyperlipidemic drug simvastatin (10 mg/kg body wt.). Dose
selection was made on the basis of acute oral toxicity study (50 mg to 5000 mg/kg body weight) as per OECD guidelines. Oral
administration of 500 mg/kg body wt. of the ethanolic extract of Hibiscus rosa sinensis flowers exhibited a significant reduction (p<0.01)
in serum lipid parameters total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipopreotein (VLDL) and increase
in high density lipoprotein (HDL) in hyperlipidemic rats in comparison with hyperlipidemic control in both models. The drug has the
potential to act as antihyperlipidemic drug

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    ABSTRACT: To access the in vitro antibacterial activity of Hibiscus rosa-sinensis (H. rosa- sinensis) flower extract against human pathogens. Antibacterial activity was evaluated by using disc and agar diffusion methods. The protein was run through poly acrylmide gel electrophoresis to view their protein profile. The results showed that the cold extraction illustrates a maximum zone of inhibition against Bacillus subtillis (B. subtillis), Escherichia coli (E. coli) viz., (17.00 ± 2.91), (14.50 ± 1.71) mm, followed by hot extraction against, E. coli, Salmonella sp. as (11.66 ± 3.14), (10.60 ± 3.09) mm. In methanol extraction showed a highest zone of inhibition recorded against B. subtillis, E. coli as (18.86 ± 0.18), (18.00 ± 1.63) mm pursued by ethanol extraction showed utmost zone of inhibition recorded against Salmonella sp. at (20.40 ± 1.54) mm. The crude protein from flower showed a maximum inhibitory zone observed against Salmonella sp., E. coli viz., (16.55 ± 1.16), (14.30 ± 2.86) mm. The flower material can be taken as an alternative source of antibacterial agent against the human pathogens. The extracts of the H. rosa-sinensis are proved to have potential antibacterial activity, further studies are highly need for the drug development.
    Asian Pacific Journal of Tropical Biomedicine 05/2012; 2(5):399-403. DOI:10.1016/S2221-1691(12)60064-1

Mukesh Singh Sikarwar