Antihyperlipidemic Effect of Ethanolic Extract of Hibiscus rosa sinensis Flowers in Hyperlipidemic Rats

RGUHS Journal of Pharmaceutical Sciences 01/2011; 1:117-122.


The antihyperlipidemic activity of Hibiscus rosa sinensis flowers ethanolic extract was investigated in triton (400 mg/kg b.w.) induced and
atherogenic diet-induced hyperlipidemic rats in comparison of a known antihyperlipidemic drug simvastatin (10 mg/kg body wt.). Dose
selection was made on the basis of acute oral toxicity study (50 mg to 5000 mg/kg body weight) as per OECD guidelines. Oral
administration of 500 mg/kg body wt. of the ethanolic extract of Hibiscus rosa sinensis flowers exhibited a significant reduction (p<0.01)
in serum lipid parameters total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipopreotein (VLDL) and increase
in high density lipoprotein (HDL) in hyperlipidemic rats in comparison with hyperlipidemic control in both models. The drug has the
potential to act as antihyperlipidemic drug

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Available from: Mukesh Singh Sikarwar, Oct 03, 2015
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    • "rosa-sinensis) belongs to the family Malvaceae. Traditionally the flowers can be used as anti asthmatic agents [2] [3] . Many chemical constituents such as cyanidin, quercetin, hentriacontane, calcium oxalate, thiamine, riboflavin, niacin and ascorbic acids have been isolated from this plant. "
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    ABSTRACT: To access the in vitro antibacterial activity of Hibiscus rosa-sinensis (H. rosa- sinensis) flower extract against human pathogens. Antibacterial activity was evaluated by using disc and agar diffusion methods. The protein was run through poly acrylmide gel electrophoresis to view their protein profile. The results showed that the cold extraction illustrates a maximum zone of inhibition against Bacillus subtillis (B. subtillis), Escherichia coli (E. coli) viz., (17.00 ± 2.91), (14.50 ± 1.71) mm, followed by hot extraction against, E. coli, Salmonella sp. as (11.66 ± 3.14), (10.60 ± 3.09) mm. In methanol extraction showed a highest zone of inhibition recorded against B. subtillis, E. coli as (18.86 ± 0.18), (18.00 ± 1.63) mm pursued by ethanol extraction showed utmost zone of inhibition recorded against Salmonella sp. at (20.40 ± 1.54) mm. The crude protein from flower showed a maximum inhibitory zone observed against Salmonella sp., E. coli viz., (16.55 ± 1.16), (14.30 ± 2.86) mm. The flower material can be taken as an alternative source of antibacterial agent against the human pathogens. The extracts of the H. rosa-sinensis are proved to have potential antibacterial activity, further studies are highly need for the drug development.
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    ABSTRACT: Introduction:Hibiscus rosa-sinensis L., distributed throughout tropics and subtropics, is useful for various purposes like ornamental, religious and therapeutic. Flowers are believed to possess haematinic and hair growth enhancing properties. At times a single plant may exhibit flowers of two different colours, may be a result of chimiral hybridization. It has dazzling cultivar of forms and colours, however the red coloured flowers are said to be best for medicinal use. The plant is reported to possess antioxidant activity. An attempt has been made to study the comparative antioxidant activity, using HPLC-DPPH method, and total phenolic as well as total flavonoid contents of four cultivars i.e. plants with red, pink, white and yellow coloured flowers of Hibiscus rosa-sinensis.Methods: The methanolic extract of the defatted samples was used for the study. The Total Phenolic content was determined by spectrophotometric method using Folin-Ciocalteu reagent whereas the total flavonoid content was estimated by colorimetric method using aluminium chloride. DPPH free radicals scavenging activity was assessed by HPLC-DPPH method. Results: All the cultivars showed presence of considerable amount of phenolic compounds, flavonoids and significant antioxidant activity. A noteworthy variation in phytochemical concentration was observed. The red cultivar revealed highest antioxidant activity, total phenolic and total flavonoid content. Conclusion: The result of present study indicated the potential of Hibiscus rosa-sinensis flowers as a natural antioxidant. The data revealed significant variations in phytochemical content among its different cultivars and these variations contribute to their studied bioactivity, i.e. in vitro antioxidant activity.
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