Article

Phytochemical analysis of Andrographis paniculata extract and its antimicrobial activity

World Journal of Microbiology and Biotechnology (Impact Factor: 1.35). 01/2009; 26:85 - 91. DOI: 10.1007/s11274-009-0146-8

ABSTRACT The present study describes the phytochemical profile and antimicrobial activity of Andrographis paniculata. For the present investigation, two samples of A. paniculata extracts, obtained by extraction in chloroform and chloroform + HCl, respectively, were compared for their antimicrobial activity and further subjected to GC-MS analysis to find out the nature of the compounds responsible for the antimicrobial activity. The antibacterial activities were assessed by measuring the diameter of the inhibition zones, MIC and MBC values. Compared to the chloroform + HCl extract, the chloroform extract showed better antimicrobial activity against all the nine pathogenic bacterial strains tested. The chloroform extract was observed to be active against the opportunistic and pathogenic gram-negative bacteria, indicating its potential application related to noscomial infections. GC-MS results revealed phenols, aromatic carboxylic acids and esters in the chloroform extract to be the molecules responsible for the antimicrobial activity of A. paniculata. This is the first report on analysis of antimicrobial components from A. paniculata, and our results confer the utility of this plant extract in developing a novel broad spectrum antimicrobial agent.

5 Bookmarks
 · 
1,108 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Influence of season and organ on antibacterial activity of Magnolia dealbata Zucc. against two phytopathogenic bacteria, Chemistry and Ecology, makes every effort to ensure the accuracy of all the information (the "Content") contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. Terms &
    Chemistry and Ecology 07/2014; · 1.07 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Developing countries have greater burden of infectious diseases. A number of factors which promote antimicrobial resistance are availability of antimicrobials without prescription, substandard antimicrobial drugs, suboptimal hygiene, immunosuppression, etc. Staphylococcus aureus is a pathogen of major concern because of its ability to cause a diverse array of diseases ranging from minor infections to life threatening septicemia and its ability to adapt to adverse environmental conditions. Methicillin resistance among clinical isolates of S. aureus is still increasing. The major mechanism is the acquisition of the mecA gene that codes for additional penicillin-binding protein2a. Limited treatments for MRSA prompted the research for novel compounds with a broad spectrum of activity and new therapeutic strategies. Medicinal plants are a significant aspect of developing a safer antibacterial principle through isolation, characterization, identification and biological studies.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Andrographis is a medicinally important genus of 26 species native to India, with greatest species diversity occurring in southern India. The present study provides the natural range of eleven species of Andrographis in Andhra Pradesh. Of these, nine species show narrow distributional range and are vulnerable to unsustainable harvesting and land use changes. As the first step towards the conservation and prioritization of the valuable taxa, this study presents data on diversity, spatial distribution and habitats of Andrographis species in the state of Andhra Pradesh.
    Proceedings of the National Academy of Sciences, India - Section B: Biological Sciences 06/2014; · 0.40 Impact Factor

Full-text

Download
189 Downloads
Available from
Jun 3, 2014