ABSTRACT We report a case of trichogenic tumor with epithelial and mesenchymal components recapitulating the formation of hair germs. The epithelial lobules were highly pigmented and affected the full thickness of the dermis, extending into the subcutaneous fat. In addition, amyloid deposits were found within the epithelial lobules and in the stroma. The overall architecture was reminiscent of hair bulbs. Problems of differential diagnosis with other trichogenic tumors and pigmented tumors are discussed.
Article: Giant melanotrichoblastoma.[Show abstract] [Hide abstract]
ABSTRACT: Trichoblastomas are benign skin tumors composed mostly of follicular germinative cells recapitulating the differentiation of hair follicles. Several variants of trichoblastomas have been reported, including pigmented trichoblastomas, melanotrichoblastomas, subcutaneous trichoblastomas, or giant trichoblastomas. We report a rare case of a pigmented trichoblastoma with abundant dendritic melanocytes. A 51-year-old Korean man had a round soft tissue mass on his back. The tumor was 6 cm in size and located in the subcutaneous fatty layer. On immunohistochemical stain for Melan A, numerous dendritic melanocytes were demonstrated in both pigmented and nonpigmented epithelial cell components. These cells were also positive for HMB45, and some of the dendritic melanocytes were positive for S-100 protein. With the aid of immunohistochemical staining, we diagnosed the tumor as a giant melanotrichoblastoma.The American Journal of dermatopathology 10/2010; 33(3):e37-40. · 1.30 Impact Factor
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ABSTRACT: Due to the proximity of the skin, subcutis, and axilla to the breast, the possibility of a "breast mass" actually representing a dermatologic lesion should be considered, particularly if the proliferation does not look characteristically "mammary" in appearance. Even more underappreciated is the scenario of a dermatologic proliferation morphologically masquerading as a breast tumor. The pathologist can fall prey to this pitfall if he/she is led to believe that the location of the tumor is the breast proper. The aim of this review is to provide an overview of dermatologic mimickers of breast lesions and helpful ways to discern between them when possible.Advances in anatomic pathology. 07/2014; 21(4):228-247.
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ABSTRACT: Pilomatricoma and matricoma are 2 benign epithelial tumours derived from the hair matrix. Although containing the same constituent cells, the silhouette differs, with matricoma comprised of a predominantly solid basaloid proliferation with only focal areas of shadow cell formation. The recently described melanocytic matricoma appears to be a similar tumor with numerous interspersed melanocytes. We studied retrospectively 28 pilomatricomas and 2 pilomatrical carcinomas to check for the presence of melanocytes using immunohistochemical staining to S-100 and Melan-A. Three cases of pilomatricoma with prominent melanocytic hyperplasia were detected, confirming this as a rare (11%) occurrence. Both cases of pilomatrical carcinoma were negative. Comparison of these tumors with a further case of melanocytic matricoma led to a critical analysis of the relationship of pilomatricoma, matricoma, and melanocytic matricoma. Although further comparison is required, we suggest that melanocytic matricoma may be simply a pigmented melanocytic variant of matricoma, in the same way as we accept pigmented pilomatricoma as a variant of pilomatricoma. In this report we provide features that may be used to discriminate matricoma and pilomatricoma and their pigmented variants.The American Journal of dermatopathology 09/2010; 32(8):769-73. · 1.30 Impact Factor