The preparation of magnetic nanoparticles for applications in biomedicine. J Phys D Appl Phys 36:R182-R197

Spanish National Research Council, Madrid, Madrid, Spain
Journal of Physics D Applied Physics (Impact Factor: 2.72). 07/2003; 36(13):R182-R197. DOI: 10.1088/0022-3727/36/13/202


This review is focused on describing state-of-the-art synthetic routes for the preparation of magnetic nanoparticles useful for biomedical applications. In addition to this topic, we have also described in some detail some of the possible applications of magnetic nanoparticles in the field of biomedicine with special emphasis on showing the benefits of using nanoparticles. Finally, we have addressed some relevant findings on the importance of having well-defined synthetic routes to produce materials not only with similar physical features but also with similar crystallochemical characteristics.

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Available from: Maria del Puerto Morales, Feb 18, 2014
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    • "In this case, the thermal energy overcomes the magnetic anisotropy energy barriers of single domain particles and results in super-paramagnetic behavior [17]. Super-paramagnetic nanoparticles have proven to be ideal for many biomedical applications such as magnetic resonance imaging, cancer treatments, biological and chemical sensing and targeted drug delivery [18] [19] [20] [21]. Due to the strong dependence of physical and particularly magnetic properties of metal nanoparticles on their shape and size [22] [23], it is important to control synthesis parameters to achieve desirable morphology and size distribution. "
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    ABSTRACT: Abstract Nickel nanoparticles were synthesized by chemical reduction method in the absence of any surface capping agent. The effect of reactants mixing rate and the volume ratio of methanol/ethanol as solvent on the morphology and magnetic properties of nickel nanoparticles were studied by design of experiment using central composite design. X-ray diffraction (XRD) technique and Transmission Electron Microscopy (TEM) were utilized to characterize the synthesized nanoparticles. Size distribution of particles was studied by Dynamic Light Scattering (DLS) technique and magnetic properties of produced nanoparticles were investigated by Vibrating Sample Magnetometer (VSM) apparatus. The results showed that the magnetic properties of nickel nanoparticles were more influenced by volume ratio of methanol/ethanol than the reactants mixing rate. Super-paramagnetic nickel nanoparticles with size range between 20 and 50 nm were achieved when solvent was pure methanol and the reactants mixing rate was kept at 70 ml/h. But addition of more ethanol to precursor solvent leads to the formation of larger particles with broader size distribution and weak ferromagnetic or super-paramagnetic behavior.
    Journal of Alloys and Compounds 06/2015; 635:118 - 123. DOI:10.1016/j.jallcom.2015.02.112 · 3.00 Impact Factor
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    • "Nanoparticles are likely to aggregate because of a large surface-tovolume ratio and associated tendency for reduction of their surface energy, long-range magnetostatic interparticle interactions and van der Waals attraction. In a biological medium (blood plasma) they will adsorb proteins (biopolymers) on their surfaces, which additionally results in formation of agglomerates and prevents from achieving the target (affected) organ [10] [11] [12]. Thus a key issue in medical applications is the surface modification of iron oxide particles by creating a very thin layer of biocompatible organic (polymer), inorganic (noble metals) or oxide (e.g. "
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    ABSTRACT: Three series of core–shell maghemite nanoparticles were prepared by a template synthesis using surface active oligoperoxides and further surface initiated grafting functional polymers, forming shell suitable for biomedical applications. Because the polymer shells prevent exchange coupling between maghemite particles, the overall magnetic properties of the samples studied are dominated by dipolar interparticle interactions. Only the sample with the highest polymer fraction displays superparamagnetic relaxation phenomena close to the room temperature. On cooling, the magnetostatic interactions lead to a disordered collective magnetic state that should be described in terms of a spin-glass phenomenology. This collective freezing cannot however be considered as a generic spin-glass phase transition at a well-defined temperature but rather as freezing to a metastable glass-like state of locally correlated structural domains (clusters) without a long-range order. A quasi static spin ordering is only achieved at temperatures much below the freezing temperature.
    Journal of Magnetism and Magnetic Materials 04/2015; 379. DOI:10.1016/j.jmmm.2014.12.002 · 1.97 Impact Factor
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    • "Exclusive properties can be achieved by incorporating magnetic nanoparticles into the biopolymer matrices (Schexnailder and Schmidt, 2009). Actually, a large number of magnetic materials have been used for abundant technological and biomedical applications, including magnetic separation, MRI contrast agent, hyperthermia, thermal ablation and tissue engineering (Kim et al., 2012; Meenach et al., 2010; Reddy et al., 2011; Tartaj et al., 2003). For the DDS area, this is one of the most interesting purposes, especially for cancer therapy, where the levels of drug release can be tuned through stimulation by an external magnetic field (Chomoucka et al., 2010). "
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    ABSTRACT: New magnetic bio-hybrid matrices for potential application in drug delivery are developed from the assembly of the biopolymer alginate and magnetic graphite nanoparticles. Ibuprofen (IBU) intercalated in a Mg–Al layered double hydroxide (LDH) was chosen as a model drug delivery system (DDS) to be incorporated as third component of the magnetic bionanocomposite DDS. For comparative purposes DDS based on the incorporation of pure IBU in the magnetic bio-hybrid matrices were also studied. All the resulting magnetic bionanocomposites were processed as beads and films and characterized by different techniques with the aim to elucidate the role of the magnetic graphite on the systems, as well as that of the inorganic brucite-like layers in the drug-loaded LDH. In this way, the influence of both inorganic components on the mechanical properties, the water uptake ability, and the kinetics of the drug release from these magnetic systems were determined. In addition, the possibility of modulating the levels of IBU release by stimulating the bionanocomposites with an external magnetic field was also evaluated in in vitro assays.
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