New growth hormone secretagogues

Letters in Peptide Science 05/2001; 8(3-5):187-193. DOI: 10.1007/BF02446516


Starting from EP 51389, a potent growth hormone secretagogue (GHS), a new series of GHS has been designed, synthesized and tested. This series was built on a gem-diamino moiety and a structure activity relationship study was performed including N-methylation of the amide bonds. Some analogues exhibited more powerful activity than Hexarelin, they were active per os on dog and have been selected as candidates for further development.

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    ABSTRACT: For Abstract see ChemInform Abstract in Full Text.
    ChemInform 09/2003; 34(38). DOI:10.1002/chin.200338226
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