Article

Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India.
ISRN Endocrinology 07/2011; 2011. DOI: 10.5402/2011/869273
Source: PubMed

ABSTRACT The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in
streptozotocin-induced (STZ; 65mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally
at 200 and 400 mg kg−1 body weight daily for 15 days. Glibenclamide (0.5mg kg−1 p. o.) was used as reference drug. Blood glucose
levels were measured on 0th, 4th, 8th, and 15th days of study. Serum biochemical parameters namely, SGOT, SGPT and ALP
were estimated. The TBARS and GSH levels of pancreas, kidney, and liver were determined. MECL significantly (P < 0.001) and
dose dependently normalized blood glucose levels and serumbiochemical parameters, decreased lipid peroxidation, and recovered
GSH as compared to those of STZ control. The present paper infers that in STZ-induced diabetic Wistar rats, C. limetta fruit peel
demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property.

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