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Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India.
ISRN Endocrinology 01/2011; 2011. DOI: 10.5402/2011/869273
Source: PubMed

ABSTRACT The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in
streptozotocin-induced (STZ; 65mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally
at 200 and 400 mg kg−1 body weight daily for 15 days. Glibenclamide (0.5mg kg−1 p. o.) was used as reference drug. Blood glucose
levels were measured on 0th, 4th, 8th, and 15th days of study. Serum biochemical parameters namely, SGOT, SGPT and ALP
were estimated. The TBARS and GSH levels of pancreas, kidney, and liver were determined. MECL significantly (P < 0.001) and
dose dependently normalized blood glucose levels and serumbiochemical parameters, decreased lipid peroxidation, and recovered
GSH as compared to those of STZ control. The present paper infers that in STZ-induced diabetic Wistar rats, C. limetta fruit peel
demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property.

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    Am. J. PharmTech Res. 01/2013; 3(5):36.
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    ABSTRACT: Objective: To investigate the therapeutic effects of methanol extract of Citrus macroptera fruit in α-amylase inhibitory activity (in vitro) and hypoglycemic activity in normal and g Mluocnotsre. induced hyperglycemic rats (in vivo). Methods: Fruits of Citrus macroptera without rind was extracted with pure methanol following cacotlidv ietyx,t raancdti honyp aongldy cteemsteicd effofer cpt riens neonrcme aol fr apths yatnodch gelmuciocsael icnodnuscteitdu ehnytpse, rαgl-ycaemmyilca srea tsin. hibitory Results: Presence of saponin, steroid and terpenoid were identified in the extract. The results smhgo/wmeLd] tahsa tc ofrmupita erexdtr atoc t ahcaadrb mosoed.e Mraotere αov-earm ayt la5s0e0 mingh/ikbgit oarnyd a 1c t0i0v0i tym g[I/Ck5g0 vdaolsuees= f(3ru.6i3t 8e依x0t.r1a9c0t) sraigtsn iafisc acnotmlyp a(Pre<d0 .t0o5 galnibde Pnc<l0a.m01i dree s(p5e mctgiv/kegly).) Irne dourcael dg lfuacstoisneg tbolloeoradn gcleu cteosste, 5le0v0e ml ign/k ngo drmosael bsilgonoidfi cgalunctloys ere ldeuvceel da tb 2lo ho da ngdlu 3c ohs e(P le<v0e.0l 5( Pa<n0d. 0P5)< a0t. 021 hr ebsupte 1c 0ti0v0e mlyg) /wkhge dreoases sgilgibneifniccalanmtlyid ree d(5u mcegd/ kisg )a lssiog nciofincsaindtelrye dre edxutcreemd egllyu csiogsnei fliecvaenlt awt itehv eFr yv ahlouuer= a23ft.e83r aadnmd iPn ivstarlauteio=n0.. 0O00v1e rianl lo rtiaml eg luefcfoescet tolerance test. Conclusion: These findings suggest that the plant may be a potential source for the development of new oral hypoglycemic agent.
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