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Ethnobotanical Survey of Plants Used in the Treatment of Haemorrhoids in South-Western Nigeria

Journal of Advances in Developmental Research 01/2011; 2:100-111.
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    ABSTRACT: AIM OF THE STUDY: The main objectives were to document traditional knowledge on the use of medicinal plants and compare medicinal plant traditions between Li and Hmong living around Limu Mountains of Hainan Island. MATERIAL AND METHODS: Information was obtained from semi-structured interviews, personal conversation and guided fieldtrips with herbalists. Quantitative methods, such as the coefficient of similarity (S), Chi-square analysis and the 'informant agreement ratio' were applied for the comparison of medicinal plant tradition between Li and Hmong. RESULTS: In all, 224 plant species grown in the study areas are still traditionally used for the treatment of various diseases. Euphorbiaceae (17 species), Rubiaceae (16 species), Papilionaceae and Poaceae (11 species respectively), Verbenaceae (10 species) and Compositae (7 species) are predominant families used by herbalists. The most species were reported to be used for injuries (25.1% of all the medicinal use-reports), digestive system disorders (24.8%), Infections/infestations (14.7%) and Muscular-skeletal System Disorders (12.3%). The coefficient of similarity (29.0%) shows a relatively high overlap of medicinal plants used by Li and Hmong. Using Chi-square analysis, it was found that habit mentions were dependent upon the culture. Infections/infestations, Injuries and Muscular-skeletal System Disorders scored high IAR value and mention in both Li and Hmong communities. CONCLUSIONS: Medicinal plants are of importance to indigenous people around Limu Mountains who still rely on medicinal plants to treat a wide range of illnesses. There is a close relationship of medicinal plant tradition between Li and Hmong who are culturally distinct.
    Journal of ethnopharmacology 06/2013; · 2.32 Impact Factor
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    ABSTRACT: Cancer is a leading cause of death worldwide and sustained focus is on the discovery and development of newer and better tolerated anticancer drugs especially from plants. The sulforhodamine B (SRB) in vitro cytotoxicity assay, sarcoma-180 (S-180) ascites and solid tumor, and L1210 lymphoid leukemia in vivo models were used to investigate the anticancer activity of root extracts of Aristolochia ringens Vahl. (Aristolochiaceae; 馬兜鈴 mǎ dōu líng). AR-A001 (IC50 values of 20 μg/mL, 22 μg/mL, 3 μg/mL, and 24 μg/mL for A549, HCT-116, PC3, and THP-1 cell lines, respectively), and AR-A004 (IC50 values of 26 μg/mL, 19.5 μg/mL, 12 μg/mL, 28 μg/mL, 30 μg/mL, and 22 μg/mL for A549, HCT-116, PC3, A431, HeLa, and THP-1, respectively), were observed to be significantly active in vitro. Potency was highest with AR-A001 and AR-A004 for PC3 with IC50 values of 3 μg/mL and 12 μg/mL, respectively. AR-A001 and AR-A004 produced significant (p < 0.05–0.001) dose-dependent inhibition of tumor growth in the S-180 ascites model with peak effects produced at the highest dose of 120 mg/kg. Inhibition values were 79.51% and 89.98% for AR-A001 and AR-A004, respectively. In the S-180 solid tumor model, the inhibition of tumor growth was 29.45% and 50.50% for AR-A001 (120 mg/kg) and AR-A004 (110 mg/kg), respectively, compared to 50.18% for 5-fluorouracil (5-FU; 20 mg/kg). AR-A001 and AR-A004 were also significantly active in the leukemia model with 211.11% and 155.56% increase in mean survival time (MST) compared to a value of 211.11% for 5-FU. In conclusion, the ethanolic (AR-A001) and dichloromethane:methanol (AR-A004) root extracts of AR possess significant anticancer activities in vitro and in vivo.
    Journal of Traditional and Complementary Medicine. 01/2015; 5(1):35–41.
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    ABSTRACT: Cancer is known to be the second most common disease-related cause of death among humans. In drug discovery programs anti-cancer chemotherapy remains quite challenging due to resistant issues. Plants used in traditional medicine are known to contribute significantly within a large proportion of the African population. A survey of the literature has led to the identification of ~400 compounds from African medicinal plants, which have shown anti-cancer, anti-proliferation, anti-tumor and/or cytotoxic activities, tested by in vitro and in vivo assays (from mildly active to very active), mainly alkaloids, terpenoids, flavonoids, coumarins, phenolics, polyacetylates, xanthones, quinones, steroids and lignans. The first part of this review series focuses on xanthones, quinones, steroids, coumarins, phenolics and other classes compounds which were not discussed in part I.
    Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) 12/2014; · 2.94 Impact Factor

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