Ethnobotanical Survey of Plants Used in the Treatment of Haemorrhoids in South-Western Nigeria

Journal of Advances in Developmental Research 01/2011; 2:100-111.
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Available from: Emmanuel Chukwuma, Sep 28, 2015
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    • "Benth., Mangifera indica L., Terminalia avicennoides Guill. & Perr.) (Soladoye et al. 2010a, 2010b, 2012 "
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    ABSTRACT: An ethnobotanical survey of plants used in the traditional treatment of infertility in females in three southwestern states of Nigeria (Oyo, Ogun, and Osun) was conducted through a structured questionnaire. Herbalists, herbsellers, and aged couples were interviewed, and their responses were documented. In all, 75 plant species belonging to 41 families of angiosperms were said to be useful in the traditional management of infertility. Some of the recipes, methods of preparation, and administration were also documented.
    Ethnobotany Research and Applications 03/2014; 12:081-090.
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    • "Pharmacological reports of investigations on the activities of the leaf material include anti-inflammatory and anti-arthritis (Iwu & Ayanwu, 1982), anti-ulcerogenic and anti-diarrhea (Nwafor and Bassey, 2007), anti-hemorrhoid property (Soladoye et al., 2011), gastroprotective (Nwidu and Nwafor, 2009); antinociceptive (Nwidu et al., 2011a); antidiarrheal mechanism (Nwidu et al., 2011b), antimicrobial (Nwidu et al., 2012a); neuropharmacological effects (Nwidu et al., 2012b), the amino acids, antioxidants and ionic profile (Nwidu et al., 2012c), anti-ulcer effects (Nwidu et al., 2012d) and anti-inflammatory and anti-pyretic effects (Nwidu et al., 2012e). Two new cinnamoyl 1-deoxyglucosides and cinnamic acid have been isolated from the leaf by semi-preparative HPLC, and the structures established by NMR (Nwidu et al., 2012b). "
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    ABSTRACT: Background: The stem-bark extract of Carpolobia lutea (Polygalaceae), used in ethno-medicine as anti-diarrhea was pharmacologically evaluated. This was the first report of assessment of the ethanolic stem extract (ESE), of C. lutea as anti-diarrhoeal agent in rats. The anti-diarrhoeal effects, acute toxicity and ionic profile are investigated and reported. Materials and methods: The acute toxicity was established using Lock's method. The anti-diarrhoeal effects were demonstrated using castor oil-induced diarrheal and fluid accumulation and its effect on normal intestinal transit. The mechanism elucidated using yohimbine, isosorbide dinitrate, and diphenoxylate. The elemental and ionic profile of ESE was established using inductively coupled argon-plasma emission spectrometer and potentiometric titration respectively. The finger print of ESE was revealed by Jasco (Tokyo, Japan), HPLC and active compounds by phytochemical screening using standard procedure. Results: The LD50 obtained is 866.025 mg/kg (i.p). The doses of 43.3, 86.6, and 173.2 mg/kg of ESE showed inhibition of castor oil-induced diarrheal (p<0.05 -0.001). The most abundant cations in the extract are potassium and phosphorus (1.00 ±0.01 and 0.80 ± 0.030 mg/g respectively); while the most abundant anions are phosphate and sulphate (33.50±7.09 and 7.19±3.29 mg/g respectively). The HPLC fingerprint of ESE revealed UV spectra of biomolecules. Phytochemical screening revealed presence of saponins, polyphenols and glycosides. Conclusion: These investigations indicate presence of bioactive and elemental substances which could play major role in diarrheal management. This investigation justifies the use of stem-bark of C. lutea in illicit gin (akpatashi), among the Effiks in Nigeria as antidiarrheal.
    African Journal of Traditional, Complementary and Alternative Medicines 01/2014; 11(2). DOI:10.4314/ajtcam.v11i2.5 · 0.56 Impact Factor
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    ABSTRACT: Purpose: To evaluate the amino acid, antioxidant and ionic profiles of Carpolobia lutea leaf (Polygalaceae) extract (CLL). Methods: The powdered leaf was macerated and subjected to gradient solvent extraction with n-hexane, chloroform, ethyl acetate and ethanol for 72 h to obtain their respective fractions. Amino acid analysis was by cation-exchange chromatography using automated amino acid analyser. Antioxidant potential was obtained by spectrophotometric assay using 2, 2-Diphenyl-1-picrylhydrazyl DPPH while elemental and ionic analyses were carried out by atomic absorption spectrophotometry and potentiometric titration, respectively. Results: Proline, alanine, serine, valine, glycine, glutamate and lysine were found in the ethanol fraction while lysine, phenyl alanine, glycine and serine were present in the ethyl acetate fraction but not in the non-polar fractions, n-hexane and chloroform. The ethyl acetate fraction contained more lysine, phenyl alanine, glycine and serine the other leaf fractions. Minimal radical scavenging activity of all the fractions was recorded. The most abundant cations in the extract were potassium and phosphorus (2.16 ± 0.05 and 1.90 ± 0.06 mg/g, respectively) while the most abundant anion was phosphate with a concentration of 23.23 ± 4.61 mg/g for the aqueous leaf fraction Conclusion: The study shows that CLL fractions contain variety of amino acids which could promote wound healing, as well as major and minor elemental ions which, as essential body electrolytes, are required for various metabolic processes in the body.
    02/2013; 11(5). DOI:10.4314/tjpr.v11i5.15
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