: “ACOMPARATIVE STUDY OF SERUM FERRITIN AND OTHER HEMATOLOGICAL PROFILES IN NORMOTENSIVE PREGNANT WOMEN AT VARIOUS STAGES OF PREGNANCY”
ABSTRACT A comparative study of serum ferritin and other haematological profiles in normotensives pregnant women at various stages of pregnancy
Jayanth kumar Puchala 1, Srinivasa Ravi Kiran suri 2, Anil kumar Pandey3
1 Tutor , Physiology, D D Medical College, Thiruvallur;, 2 PhD Scholar Physiology , GSL Medical College Rajahmundry; 3 Associate Professor, Physiology, GSL Medical College Rajahmundry
Background: Anemia during pregnancy is considered as an established risk factor for both mother and fetus. Serum ferritin is the most sensitive parameter of negative iron balance, as it decreases only in the presence of true iron deficiency as with transferrin saturation.
Aims and objectives: The aim of the present study was to compare the normal serum ferritin levels and haematogical parameters between non-pregnant women and pregnant women in all three trimesters.
Materials and Methods:The study was conducted on 20-30 years aged pregnant and nonpregnant women. Ferritin, hemoglobin, blood indices, RBC calculations were done at the central lab in ASRAM'S, Eluru, A.P.serum ferritin level was assessed by UBI MAGIWEL Enzyme immuno assay ferritin kit. with the help of ELISYS-UNO instrument.
Results and conclusion: Progressive stages of iron deficiency can be evaluated by measurements of plasma ferritin, transferrin saturation; Both hemoglobin and haematocrit measurements and the ratio of zinc protoporphyrin to heme. By contrast, the zinc protoporphyrin; heme ratio and hemoglobin levels are affected by chronic infection and other features that mimic Iron deficiency anaemia (IDA), when iron is adequate. Serum ferritin levels showed significantly lowest values in 2nd trimester of pregnacy with slight increase again in 3rd trimester of pregnancy. The results of this study also indicated that the fall in MCV, MCH and MCHC showed a linear correlation with serum ferritin level.
Key words: Ferritin, haematological profiles, pregnancy