Article

Increased pulse and blood pressure associated with desipramine treatment of bulimia nervosa.

Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
Journal of Clinical Psychopharmacology (impact factor: 4.1). 07/1992; 12(3):163-8. pp.163-8
Source: PubMed

ABSTRACT The cardiovascular effects of desipramine were assessed in 74 young women with bulimia nervosa participating in a 6-week double-blind, placebo-controlled study. Desipramine treatment was associated with significant increases in pulse, reclining systolic and diastolic blood pressures, and orthostatic hypotension. These effects were clearly evident in the first week of treatment and remained relatively unchanged during the subsequent 5 weeks. The mean increases in reclining systolic and diastolic pressures were approximately 10 mm Hg. Data from 16 patients treated for an additional 2 months indicated that most of the effects of desipramine on blood pressure diminished over time, whereas the effects on pulse persisted. These results differ from the commonly expected cardiovascular effects of tricyclic anti-depressants in adults. Evidence from the current study and from other reports suggests that the cardiovascular effects of tricyclic antidepressants are age-dependent.

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Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

16 patients
 
adults
 
blood pressure
 
bulimia nervosa
 
cardiovascular effects
 
Desipramine treatment
 
diastolic blood pressures
 
diastolic pressures
 
expected cardiovascular effects
 
mean increases
 
orthostatic hypotension
 
placebo-controlled study
 
reclining systolic
 
significant increases
 
subsequent 5 weeks
 
tricyclic anti-depressants
 
tricyclic antidepressants
 
unchanged
 

B T Walsh