Clinical and histologic features of vulvar carcinomas analyzed for human papillomavirus status: evidence that squamous cell carcinoma of the vulva has more than one etiology.
ABSTRACT The association between the human papillomavirus (HPV) and malignant neoplasms of the uterine cervix is well established; however, its role in the pathogenesis of vulvar cancer has not been well defined. This study correlates the clinical and histopathologic features of 21 invasive carcinomas of the vulva with the presence of HPV DNA as detected by Southern blot and polymerase chain reaction (PCR) analysis. By one or both techniques, HPV DNA was detected in 10 of the 21 tumors analyzed; all HPVs containing tumors hybridized with HPV-16 probes, although PCR also detected HPV-6 in two of the HPV-16-containing tumors. No HPV-18 DNA was detected in any tumor by PCR or Southern blot hybridization. Both the invasive cancer and the surrounding intraepithelial disease tended to display histopathologic features that usually could distinguish HPV-associated cancers from those without HPV DNA. The intraepithelial lesions associated with HPV-containing tumors were of the bowenoid type with koilocytosis, while tumors lacking HPV generally demonstrated a simplex type of intraepithelial lesion. Invasive tumors with no viral DNA were more frequently keratinizing than the HPV-containing cancers. Race, parity, hormonal therapy, and alcohol use did not affect the HPV status; however, HPV DNA was more prevalent in the tumors of younger women and in those with a history of tobacco use. Human papillomavirus status had no impact on the stage of disease or its prognosis. These findings identify two subsets of vulvar carcinoma cases based on HPV hybridization data and the histopathologic characteristics of the tumor.
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ABSTRACT: In this paper the authors survey some recent results in complexity-theoretic model theory and algebra. The paper contains 9 sections. Sections 1-5 are devoted to the complexity-theoretic model theory, which deals with model existence questions such as the following: given a recursive model A, is there a polynomial time (exponential time, polynomial space etc.) model ℬ which is isomorphic to A. In sections 1 and 2 a general introduction to complexity-theoretic model theory is provided and basic definitions and notations are given. Section 3 contains lemmas which are useful for building models with standard universes. In sections 4 and 5 the authors survey the main existence theorems for feasible models and various feasible categoricity results. Sections 6-9 are devoted to the second theme of the paper, which the authors call complexity-theoretic algebra, and where a given polynomial time structure is fixed and the properties of that structure are explored. In section 6 the authors give an introduction to complexity-theoretic algebra. In section 7 they focus on the structure of the binary and tally representation of an infinite-dimensional vector space over a polynomial time field. In section 8 the authors consider the semilattice of NP ideals of the binary and tally representation of the free Boolean algebra. Finally, in section 9 they give conclusions and some directions for further work.