CSF GABA in depressed patients and normal controls

National Institute of Mental Health, Bethesda, Maryland.
Psychological Medicine (Impact Factor: 5.94). 09/1991; 21(3):613-8. DOI: 10.1017/S0033291700022248
Source: PubMed


The inhibitory neurotransmitter gamma-aminobutyric acid (GABA) has been implicated in the pathophysiology of depression. Therefore, we examined cerebrospinal fluid (CSF) levels of GABA in depressed patients (N = 25) and normal controls (N = 20). There was no significant difference between the groups. However, among the depressed patients the subgroup of unipolar melancholic patients (N = 13) had significantly lower CSF levels of GABA than the rest of the depressed patients (N = 12). There was no significant difference for CSF levels of GABA between depressed patients who were (N = 14) or were not (N = 11) cortisol non-suppressors. It was of interest that among the controls there was a significant negative correlation between CSF levels of GABA and CSF levels of norepinephrine.

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    • "In the same study cohort, we previously reported reduced cortical GABA levels in TRD subjects compared to non-TRD and HC (Price et al., 2009). Other studies have found low cortical, CSF, and plasma GABA levels to be associated with anhedonic symptoms and melancholic depression (Gabbay et al., 2012; Petty et al., 1992; Roy et al., 1991; Sanacora et al., 2004). Levinson and colleagues have shown GABA-A receptor neurophysiological activity to be selectively impaired in TRD patients compared to non-TRD, euthymic MDD, and HC (Levinson et al., 2010). "
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    European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology 05/2015; 25(8). DOI:10.1016/j.euroneuro.2015.04.025 · 4.37 Impact Factor
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    • "• 17 MDD patients ( Petty and Schlesser 1981 ) • 23 euthymic medication - free BPD patients ( Berrettini and others 1983 ) • 58 MDD patients ( Petty and Sherman 1984 ) • 133 patients with MDD , BPD , and mania ( Petty and others 1990 ) • 77 male patients with MDD ( Petty and others 1992 ) • BPD patients in manic ( n = 24 ) and in depressed states ( n = 33 ) ( Petty and others 1993a ) • 46 male patients with MDD ( Petty and others 1995 ) Decreased CSF GABA Levels • 17 depressed patients including 10 MDD and 5 BPD ( Gold and others 1980 ) • 6 treated patients with depressive syndromes ( Zimmer and others 1980 ) • 26 depressed patients ( Gerner and Hare 1981 ) • 13 depressed patients with MDD ( n = 10 ) and BPD ( n = 3 ) ( Kasa and others 1982 ) • 9 euthymic medication - free MDD and BPD patients ( Berret - tini and others 1983 ) • 41 depressed patients with 1 MDD ( n = 10 ) and BPD ( n = 30 ) ( Gerner and others 1984 ) Unaltered CSF GABA Levels • 25 longer recovered euthymic BPD patients ( Berrettini and others 1986 ) • 25 depressed patients , 13 were melancholic ( Roy and others 1991 ) "
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    • "Therefore, our findings of positive correlations between KYN and 3-HAA and striatal tCho suggest that pathways involved in cellular survival may be more relevant to the pathogenesis of melancholic adolescent MDD compared to other subtypes of MDD. This notion is supported by findings from adult MDD studies documenting reductions of γaminobutyric acid (GABA) concentrations in the plasma (Petty et al., 1992), the CSF (Roy et al., 1991), and the occipital lobe (Sanacora et al., 2004) as well as increased glutamate brain concentrations (Sanacora et al., 2004), which were more pronounced in melancholic MDD patients compared to controls. "
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