Classification of coryneform bacteria associated with human urinary tract infection (group D2) as Corynebacterium urealyticum sp. nov.

National Collection of Type Cultures, Central Public Health Laboratory, London, United Kingdom.
International journal of systematic bacteriology (Impact Factor: 2.27). 02/1992; 42(1):178-81. DOI: 10.1099/00207713-42-1-178
Source: PubMed

ABSTRACT Urealytic strains of coryneform bacteria that are designated Corynebacterium group D2 and are isolated from human urine are a cause of urinary tract infections. Cell wall and lipid analyses confirmed that these organisms are members of the genus Corynebacterium but can be separated from other species in the genus on the basis of DNA base composition and DNA-DNA hybridization values. Biochemically, strains in this taxon can be distinguished from other Corynebacterium spp. by their failure to produce acid from carbohydrates, by their failure to reduce nitrates, and by their ability to hydrolyze urea. We regard these bacteria as a new species of the genus Corynebacterium and propose the name Corynebacterium urealyticum. The type strain is strain NCTC 12011 (= ATCC 43042).

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    ABSTRACT: A 93-year-old woman with neurogenic bladder was admitted to our hospital because of impaired consciousness. Her urine culture revealed urease-test-positive Corynebacterium urealyticum. She was diagnosed with hyperammonemia due to an obstructive urinary tract infection that was caused by urease-producing bacteria. The patient showed rapid improvement of impaired consciousness and hyperammonemia after urine analysis. It is necessary to consider obstructive urinary tract infection as a differential diagnosis of hyperammonemia, which commonly occurs in urinary tract infections owing to the presence of urease-producing bacteria. Relief from obstruction is the most important treatment for hyperammonemia caused by this mechanism.
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    ABSTRACT: Urinary stones are prevalent and Corynebacterium urealyticum, a urease-positive bacteria, is a frequent urinary tract pathogen. However, the association of this organism with urinary stones is not sufficiently studied in Iran. This study was carried out to determine the prevalence of C. urealyticum in patients with urinary stones referred to the urology sections of Tehran University of Medical Sciences. This study was performed using case-control method. A total of 150 urine samples from patients with urinary stones and the same number from the control group without urinary stones or infection were collected. The two sets of samples were cultured and biochemically identified. The pH of urine samples also measured with pH paper. C. urealyticum was detected in 11.34% of cases which was significantly higher than that in control group (P < 0.01). The frequency of alkaline urine was four times more in the patients than those in control group which was statistically significant (P< 0.01). According to the results, C. urealyticum, which is known to cause alkaline urine, might enhance formation of stones. Further studies using cohort or experimental methods are recommended. Acta Medica Iranica, 42(4): 285-288; 2004
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    ABSTRACT: Background Urinary tract infections caused by Corynebacterium urealyticum are uncommon in veterinary medicine. Encrusted cystitis, encrusted pyelitis and uroliths have been described as complications in humans, but only encrusted cystitis and cystoliths have been reported in dogs so far. Because C. urealyticum is usually resistant to all standard antibacterial drugs, antimicrobial treatment and elimination of this microorganism are challenging.Case reportAn 11-month-old female spayed mixed-breed dog was evaluated because of a C. urealyticum urinary tract infection, mineralisation within both renal pelvises and failure of antimicrobial treatment. Physical examination, haematology and biochemistry were unremarkable. Radiographic and ultrasonographic examinations confirmed bilateral nephrolithiasis. Voided uroliths were composed of 100% carbonate apatite. Urinalysis was indicative of bacterial infection. Aerobic culture of the urine and 16S rRNA sequencing identified significant growth of C. urealyticum and susceptibility testing revealed sensitivity to only vancomycin and linezolid.Conclusion Treatment with the oxazolidinone antibacterial, linezolid, in combination with a urine-acidifying diet resulted in elimination of this multiresistant microorganism and complete resolution of nephrolithiasis.
    Australian Veterinary Journal 05/2014; 92(5). · 0.92 Impact Factor


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