Classification of Coryneform Bacteria Associated with Human Urinary Tract Infection (Group D2) as Corynebacterium urealyticum sp. nov.

National Collection of Type Cultures, Central Public Health Laboratory, London, United Kingdom.
International journal of systematic bacteriology (Impact Factor: 2.27). 02/1992; 42(1):178-81. DOI: 10.1099/00207713-42-1-178
Source: PubMed


Urealytic strains of coryneform bacteria that are designated Corynebacterium group D2 and are isolated from human urine are a cause of urinary tract infections. Cell wall and lipid analyses confirmed that these organisms are members of the genus Corynebacterium but can be separated from other species in the genus on the basis of DNA base composition and DNA-DNA hybridization values. Biochemically, strains in this taxon can be distinguished from other Corynebacterium spp. by their failure to produce acid from carbohydrates, by their failure to reduce nitrates, and by their ability to hydrolyze urea. We regard these bacteria as a new species of the genus Corynebacterium and propose the name Corynebacterium urealyticum. The type strain is strain NCTC 12011 (= ATCC 43042).

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Available from: Pedro Luis Valero-Guillén, Jan 28, 2015
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    • "Red blood cells/high power field y White blood cells/high power field small animals (Elad et al 1992, Gomez et al 1995, Suarez et al 2002) and moreover, to the authors' knowledge, only one report describes two cases of UTI caused by this organism in cats (Bailiff et al 2005). C urealyticum, previously known as the Corynebacterium group D 2 (Pitcher et al 1992), is a commensal microrganism of the human skin whose opportunistic pathogenic role in urine has been demonstrated in vitro and in vivo (Meria and Jungers 2000). The source for cats is less clear, but microrganisms identified as Corynebacterium species have been isolated as part of the normal flora of the feline genital tract (Strom Holst et al 2003). "
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    ABSTRACT: Corynebacterium urealyticum is an uncommon cause of urinary tract infections in cats. However, it is difficult to diagnose and if left untreated it may result in irreversible bladder lesions. C urealyticum is a multiantibiotic-resistant bacterium whose culture requires special care. Risk factors for the occurrence of this infection include urological procedures, foreign bodies, bladder mucosa abnormalities, immuno-suppressed states and antibiotic treatment. This report describes an unusual case of C urealyticum urinary infection in a young cat with pre-existing urethral obstruction. C urealyticum was isolated in pure cultures from two urine samples. Clinical and ultrasound features, results of the urinalysis and urine culture are described as well as therapeutic treatment and eventual favourable outcome to treatment with amoxycillin-clavulanic acid.
    Journal of Feline Medicine & Surgery 07/2008; 10(3):269-73. DOI:10.1016/j.jfms.2007.12.003 · 1.16 Impact Factor
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    ABSTRACT: Urinary stones are prevalent and Corynebacterium urealyticum, a urease-positive bacteria, is a frequent urinary tract pathogen. However, the association of this organism with urinary stones is not sufficiently studied in Iran. This study was carried out to determine the prevalence of C. urealyticum in patients with urinary stones referred to the urology sections of Tehran University of Medical Sciences. This study was performed using case-control method. A total of 150 urine samples from patients with urinary stones and the same number from the control group without urinary stones or infection were collected. The two sets of samples were cultured and biochemically identified. The pH of urine samples also measured with pH paper. C. urealyticum was detected in 11.34% of cases which was significantly higher than that in control group (P < 0.01). The frequency of alkaline urine was four times more in the patients than those in control group which was statistically significant (P< 0.01). According to the results, C. urealyticum, which is known to cause alkaline urine, might enhance formation of stones. Further studies using cohort or experimental methods are recommended. Acta Medica Iranica, 42(4): 285-288; 2004
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    ABSTRACT: A 93-year-old woman with neurogenic bladder was admitted to our hospital because of impaired consciousness. Her urine culture revealed urease-test-positive Corynebacterium urealyticum. She was diagnosed with hyperammonemia due to an obstructive urinary tract infection that was caused by urease-producing bacteria. The patient showed rapid improvement of impaired consciousness and hyperammonemia after urine analysis. It is necessary to consider obstructive urinary tract infection as a differential diagnosis of hyperammonemia, which commonly occurs in urinary tract infections owing to the presence of urease-producing bacteria. Relief from obstruction is the most important treatment for hyperammonemia caused by this mechanism.
    Central European Journal of Medicine 10/2013; 8(5). DOI:10.2478/s11536-013-0202-5 · 0.15 Impact Factor
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