Prophylactic and therapeutic application of Propionibacterium avidum KP-40 in swine and calves with acute enzootic bronchopneumonia.
ABSTRACT The usefulness of the prophylactic or therapeutic application of Propionibacterium avidum KP-40, a potent stimulator of the monocyte-macrophage-system, was demonstrated in piglets and calves. After a 3-month-period of observation PA-treated piglets showed a significantly improved development (decreased number of infections, gain of body weight). In piglets and calves the therapeutic use of PA together with oxytetracycline proved to be superior in the treatment of acute endemic enzootic bronchopneumonia (AEB) as compared to groups of animals receiving PA or oxytetracycline alone.
- SourceAvailable from: Małgorzata Pomorska-Mól
Article: Adjuvant properties of herbs[show abstract] [hide abstract]
ABSTRACT: The term adjuvant is derived from the Latin word adjuvare, which means to help. In veterinary medicine the most popular adjuvants are aluminium hydroxide and oil adjuvants, but these chemical adjuvants may cause many adverse reactions. Saponins from various herbs are mentioned among potential adjuvants. To date, saponins with adjuvant activity have been identified, among others, in Panax ginseng Astragalus species, Cochinchina momordica, Quillaja saponaria, Polygala senega, Chenopodium quinoa, and Acacia concinna. The mechanisms of immune-stimulating action of saponins have not been clearly understood. It is probable that saponins enhance cross-presentation of exogenous antigens into MHC class I pathway, thereby promoting the cellular response. Moreover, they are likely to increase the permeability of the mucosal epithelium and facilitate the entry of antigens into the bloodstream or the interaction between the mucosal-associated lymphoid tissue and antigens. Saponins induce a mixed Th1/Th2 response, which stimulates the production of typical cytokines (INF-γ, IL-4 or IL-10). Data presented in this article indicate clearly that saponins possess strong adjuvant properties and do not cause adverse reactions. However, a great deal of research is still needed to explain the mechanism of fitoadjuvant activityMedycyna weterynaryjna 01/2011; 67:449-452. · 0.20 Impact Factor