Photochemical Coatings for the Prevention of Bacterial Colonization
Department of Biochemistry, North Dakota State University, Fargo 58105.Journal of Biomaterials Applications (Impact Factor: 2.2). 11/1991; 6(2):131-56. DOI: 10.1177/088532829100600203
Biomaterials are being used with increasing frequency for tissue substitution. Implantable, prosthetic devices are instrumental in the saving of patients' lives and enhancing the quality of life for many others. However, the greatest barrier to expanding the use of biomedical devices is the high probability of bacterial adherence and proliferation, causing very difficult and often untreatable medical-device centered infections. The difficulty in treating such infections results in great danger to the patient, and usually retrieval of the device with considerable pain and suffering. Clearly, development of processes that make biomedical devices resistant to bacterial adherence and colonization would have widespread application in the field of biomedical technology. A photochemical surface modification process is being investigated as a generic means of applying antimicrobial coatings to biomedical devices. The photochemical process results in covalent immobilization of coatings to all classes of medical device polymers. A discussion of the photochemical surface modification process and preliminary results demonstrating the success of photochemical coatings in formulating microbial-resistant surfaces are presented in this paper.
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ABSTRACT: A constrained anti-Hebbian algorithm that is used for processing complex signals is presented. It is shown that the algorithm adaptively extracts the eigenvector associated with the smallest eigenvalue of the correlation matrix of the input signal. The operation of the algorithm is simple, similar to that of the LMS (least mean square) algorithm, and it can be applied to an adaptive prediction-error filter directly, giving an estimate of the parameters that is optimal in the total least-squares sense. Simulation results on estimating the frequencies of sinusoids corrupted by white noise are presentedCircuits and Systems, 1992. ISCAS '92. Proceedings., 1992 IEEE International Symposium on; 06/1992
Article: Bacterial biofilms[Show abstract] [Hide abstract]
ABSTRACT: Over the review period, a significant amount of literature has been published documenting the impact of biofilms on engineered and biomedical systems. Reactor systems and analytical techniques have evolved to study the molecular chemistry and microbial ecology within biofilm layers only tens of micrometers thick, and various protocols have been developed to control cell adhesion and biofilm formation.Current Opinion in Biotechnology 05/1993; 4(2):197-204. DOI:10.1016/0958-1669(93)90125-G · 7.12 Impact Factor
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ABSTRACT: The structure and properties of photoreactive polyacrylamide thin films suitable for medical devices are presented. Using a solution deposition process, we report on the influences of polymer concentration, substrate residence time in solution and UV illumination upon the film structure, wettability and frictional properties. Ellipsometry, atomic force microscopy and lateral force microscopy show that increasing polymer concentration and illumination increased the film thickness and uniformity. Dynamic contact angles and frictional coefficients of the modified surfaces depend upon the film structure and thickness for films less than 40Å thick. We also demonstrate the potential of lateral force microscopy for investigating tribology at the nanoscale level.Colloids and surfaces B: Biointerfaces 12/1993; 1(6):349-355. DOI:10.1016/0927-7765(93)80029-X · 4.15 Impact Factor
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