Photochemical Coatings for the Prevention of Bacterial Colonization
Department of Biochemistry, North Dakota State University, Fargo 58105.Journal of Biomaterials Applications (Impact Factor: 2.2). 11/1991; 6(2):131-56. DOI: 10.1177/088532829100600203
Biomaterials are being used with increasing frequency for tissue substitution. Implantable, prosthetic devices are instrumental in the saving of patients' lives and enhancing the quality of life for many others. However, the greatest barrier to expanding the use of biomedical devices is the high probability of bacterial adherence and proliferation, causing very difficult and often untreatable medical-device centered infections. The difficulty in treating such infections results in great danger to the patient, and usually retrieval of the device with considerable pain and suffering. Clearly, development of processes that make biomedical devices resistant to bacterial adherence and colonization would have widespread application in the field of biomedical technology. A photochemical surface modification process is being investigated as a generic means of applying antimicrobial coatings to biomedical devices. The photochemical process results in covalent immobilization of coatings to all classes of medical device polymers. A discussion of the photochemical surface modification process and preliminary results demonstrating the success of photochemical coatings in formulating microbial-resistant surfaces are presented in this paper.
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ABSTRACT: A constrained anti-Hebbian algorithm that is used for processing complex signals is presented. It is shown that the algorithm adaptively extracts the eigenvector associated with the smallest eigenvalue of the correlation matrix of the input signal. The operation of the algorithm is simple, similar to that of the LMS (least mean square) algorithm, and it can be applied to an adaptive prediction-error filter directly, giving an estimate of the parameters that is optimal in the total least-squares sense. Simulation results on estimating the frequencies of sinusoids corrupted by white noise are presentedCircuits and Systems, 1992. ISCAS '92. Proceedings., 1992 IEEE International Symposium on; 06/1992
Article: Bacterial biofilms[Show abstract] [Hide abstract]
ABSTRACT: Over the review period, a significant amount of literature has been published documenting the impact of biofilms on engineered and biomedical systems. Reactor systems and analytical techniques have evolved to study the molecular chemistry and microbial ecology within biofilm layers only tens of micrometers thick, and various protocols have been developed to control cell adhesion and biofilm formation.Current Opinion in Biotechnology 05/1993; 4(2):197-204. DOI:10.1016/0958-1669(93)90125-G · 7.12 Impact Factor
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ABSTRACT: Sutures are the origin of some bacterial infections. In all cases, adhesion of cells appears as the main event in the development of these pathologies. To determine the efficiency of bactericidal products grafted on surgical threads, four strains, belonging to three genera (Staphylococcus, Pseudomonas and Escherichia) have been used. The numbers of attached bacteria, after immersion of threads in contaminated biological liquids, were evaluated and we studied the interferences of proteins. In some cases, colonization of threads was significantly reduced by grafting, without increase of cytotoxicity.Colloids and surfaces B: Biointerfaces 03/1994; 2(1-3):127-131. DOI:10.1016/0927-7765(94)80027-8 · 4.15 Impact Factor
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