Differential sensitivity of calbindin and PARV immunoreactive cells in the striatum to excitotoxins

Department of Anatomy, School of Medicine, University of Auckland, New Zealand.
Brain Research (Impact Factor: 2.83). 05/1991; 546(2):329-35. DOI: 10.1016/0006-8993(91)91497-O
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ABSTRACT The neurotoxic effects of ibotenic acid, quinolinic acid and kainic acid on cells in the rat striatum were investigated using immunocytochemistry with antibodies to the calcium binding proteins, calbindin and parvalbumin. The results showed that both ibotenic acid and quinolinic acid affected calbindin and parvalbumin cells to the same extent. However, parvalbumin immunopositive neurons were more sensitive than calbindin immunopositive neurons to the neurotoxic effects of kainic acid. Although the reason for this increased sensitivity of parvalbumin striatal neurons to kainic acid is unclear, these results suggest that the neurotoxicity produced by kainic acid is different to that occurring with quinolinic acid and ibotenic acid.

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    • "PV(ϩ) interneurons are thought to exert an inhibitory control over excitatory pyramidal cells through recurrent inhibition; CR(ϩ) interneurons , on the other hand, mainly establish synapses with other interneurons thereby supporting the synchronization of local neuronal networks (Gulyas et al 1996). It is interesting to note that PV(ϩ) interneurons seem to be more vulnerable towards excitotoxicity than other subpopulations, especially than the CR(ϩ) subtype (Lukas and Jones 1994; Waldvogel et al 1991). "
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    • "Although the physiological significance of these calcium-binding proteins in the SC is unclear, based on findings in other brain regions, their function has been linked to the modulation of neuronal firing patterns (Chard et al. 1993; Du et al. 1996; Kawaguchi and Kubota 1993; Li et al. 1995). In addition, their calcium buffering capacity may play an especially critical role in protection from N-methyl-D-aspartic acid (NMDA)-induced excitotoxicity (Waldvogel et al. 1991) that can accompany high levels of evoked activity. "
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    Experimental Brain Research 01/2002; 141(4):460-70. DOI:10.1007/s00221-001-0908-5 · 2.17 Impact Factor
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    • "BrdU ϩ striatal cells expressed calbindin-D28K, a marker of medium spiny neurons of the caudate putamen (Waldvogel et al., 1991; Burke and Baimbridge, 1993) (Fig. 10). Similarly, we found an abundance of BrdU ϩ striatal cells that coexpressed GAD67, a characteristic marker for GABAergic neurons (Fig. 10). "
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