Influenza vaccination in the prevention of acute otitis media in children

Department of Pediatrics, University of Turku, Finland.
American journal of diseases of children (1960) 05/1991; 145(4):445-8.
Source: PubMed

ABSTRACT We studied a new approach to the prevention of acute otitis media through the administration of influenza vaccine to 187 day-care center children aged 1 to 3 years before the influenza A epidemic of 1988-1989. The control group consisted of 187 unvaccinated children of similar age and background. During the 6-week study period, influenza A infection was diagnosed in five (3%) of 187 vaccinees and in 29 (16%) of 187 controls. Acute otitis media developed in three (60%) of five vaccinees with an influenza A infection compared with 18 (67%) of 27 controls (excluded were two children with a double viral infection). The incidence of acute otitis media associated with influenza A was reduced by 83% in the vaccinees. The total number of children with acute otitis media in the vaccine group was 35, compared with 55 in the control group, disclosing a 36% reduction among the vaccinees. We conclude that influenza vaccination decreases the incidence of acute otitis media in children during an influenza A epidemic, suggesting also that other vaccines against respiratory viruses may be an effective way to reduce the incidence of acute otitis media.

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    • "But, it was evaluated that AOM encountered in vaccinated cases was normal and it was concluded that vaccination was still useful, because of the mild course of disease. In two distinct studies, it was showed that influenza vaccination before flu season decreased AOM incidence by 32 and 36% (Heikkinen et al., 1991; Clements et al., 1995). With another influenza vaccine given intranasally, influenza proved by culture was prevented by 93% and AOM incidence was decreased by 30% (Belshe et al., 1998). "
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    • "Influenza vaccination is the primary method of prevention and control of influenza in persons with COPD. It can reduce influenza-related respiratory illness, physician visits, hospitalization, and death (OTA 1981; Patriarca et al 1986; Heikkinen et al 1991; Mullooly et al 1994; Gross et al 1995; Bridges 2000; Anthonisen 2002). Influenza vaccination levels increased during the 1990s, but they are lower than 50% in high-risk patients in the US and other developed countries (Harper et al 2005). "
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    • "The proportion of AOM attributed to influenza infection compares with the 32–36% reduction rate found with the use of trivalent, inactivated influenza vaccine in day care center children [18] [19] and with the 30% reduction rate of febrile acute otitis media in children 15–71 months of age [20] immunized with the live attenuated influenza vaccine. Most of AOM cases (76%) and 9/10 of cases with croup among influenza positive patients occurred in children under 5 years of age. "
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