Influenza vaccination in the prevention of acute otitis media in children
ABSTRACT We studied a new approach to the prevention of acute otitis media through the administration of influenza vaccine to 187 day-care center children aged 1 to 3 years before the influenza A epidemic of 1988-1989. The control group consisted of 187 unvaccinated children of similar age and background. During the 6-week study period, influenza A infection was diagnosed in five (3%) of 187 vaccinees and in 29 (16%) of 187 controls. Acute otitis media developed in three (60%) of five vaccinees with an influenza A infection compared with 18 (67%) of 27 controls (excluded were two children with a double viral infection). The incidence of acute otitis media associated with influenza A was reduced by 83% in the vaccinees. The total number of children with acute otitis media in the vaccine group was 35, compared with 55 in the control group, disclosing a 36% reduction among the vaccinees. We conclude that influenza vaccination decreases the incidence of acute otitis media in children during an influenza A epidemic, suggesting also that other vaccines against respiratory viruses may be an effective way to reduce the incidence of acute otitis media.
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- "But, it was evaluated that AOM encountered in vaccinated cases was normal and it was concluded that vaccination was still useful, because of the mild course of disease. In two distinct studies, it was showed that influenza vaccination before flu season decreased AOM incidence by 32 and 36% (Heikkinen et al., 1991; Clements et al., 1995). With another influenza vaccine given intranasally, influenza proved by culture was prevented by 93% and AOM incidence was decreased by 30% (Belshe et al., 1998). "
ABSTRACT: with 80 cases. Their age ranged from 2 -6. One fourth of the cases were preschoolers. The diagnosis of acute middle ear infection was confirmed by an otolaryngologist following a pediatrician and paracentesis that was performed. Bacterial culture was done in regular conditions and antibacterial resistance was assessed with disk diffusion method. Streptococcus pneumoniae was the most frequent etiologic agent. It was followed by Haemophilus influenzae (15%) and Staphylococcus aureus (6%) in order of frequency. The penicillin resistance rate of pneumococci was 24%.African journal of microbiology research 03/2010; 4:289-292. · 0.54 Impact Factor
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- "Influenza vaccination is the primary method of prevention and control of influenza in persons with COPD. It can reduce influenza-related respiratory illness, physician visits, hospitalization, and death (OTA 1981; Patriarca et al 1986; Heikkinen et al 1991; Mullooly et al 1994; Gross et al 1995; Bridges 2000; Anthonisen 2002). Influenza vaccination levels increased during the 1990s, but they are lower than 50% in high-risk patients in the US and other developed countries (Harper et al 2005). "
ABSTRACT: Despite recommendations for annual vaccination against influenza, more than half of patients with chronic obstructive pulmonary disease (COPD) in developed countries do not receive this vaccine. Influenza is characterized by its potentially of causing epidemics and by excess morbidity and mortality in patients with COPD and other chronic medical conditions. Good evidence of the efficacy, effectiveness, and cost-effectiveness of influenza vaccination underlines the recommendation of use in patients with COPD. Influenza vaccination could reduce influenza-related complications and exacerbations in patients with COPD, therefore reducing hospitalizations and deaths. Each year, all persons with COPD should be vaccinated with the inactivated trivalent influenza vaccine containing the most frequent two influenza A viral strains and one influenza B viral strain detected in the influenza season of the previous year. To achieve a 100% vaccination rate in patients with COPD, all patients with COPD registered in health insurance companies and attended in health centers and specialized clinics should be vaccinated during the immunization period (October-December). Antiviral therapies could be used as an adjunct to vaccination and to reduce influenza transmission in outbreaks. Antiviral therapies could reduce the duration and complications of influenza when administered within two days of the onset of illness. Research is necessary for new antiviral therapies that could prevent influenza with cost-effectiveness similar to the influenza vaccine.International Journal of COPD 02/2007; 2(1):41-53. DOI:10.2147/copd.2007.2.1.41 · 2.73 Impact Factor
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- "The proportion of AOM attributed to influenza infection compares with the 32–36% reduction rate found with the use of trivalent, inactivated influenza vaccine in day care center children   and with the 30% reduction rate of febrile acute otitis media in children 15–71 months of age  immunized with the live attenuated influenza vaccine. Most of AOM cases (76%) and 9/10 of cases with croup among influenza positive patients occurred in children under 5 years of age. "
ABSTRACT: Decisions regarding the introduction of influenza immunization in healthy children require an accurate evaluation of influenza disease burden not only in the inpatient but also in the outpatient setting. We prospectively examined the impact of virologically confirmed influenza in 1462 outpatient children (> or = 6 months to < 14 years) and their families, during two consecutive influenza seasons. Influenza was documented in 573/1462 (39%) outpatients with febrile respiratory illness and accounted for 13.5% of all outpatient visits during the 14 weeks of each season. Acute otitis media (AOM) was the most common complication (18.5%) and about 40% of influenza positive patients received antibiotics. AOM and antibiotic use were more common in children younger than 5 years of age who accounted for 58% of all patients. For each child sick with influenza a mean of 1.34 workdays were lost by the parents. Family members of influenza positive children were more likely to develop a secondary respiratory illness and to require medical visits and antibiotic prescriptions. Influenza is associated with a heavy morbidity burden in the community that may be reduced considerably with the implementation of immunization in children younger than 5 years of age.Vaccine 09/2006; 24(33-34):5970-6. DOI:10.1016/j.vaccine.2006.05.006 · 3.49 Impact Factor