A longitudinal study of growth velocity and development of secondary gender characteristics versus onset of idiopathic scoliosis.
ABSTRACT This study focused on evaluating the impact of the adolescent growth spurt on the onset of idiopathic scoliosis. A total of 698 students (362 girls and 336 boys aged nine to 12 years) were followed for three years to study their growth in the pubertal period and changes in spinal status. Every six months measurements were taken of body height and the development of secondary gender characteristics was recorded. The onset of the adolescent growth spurt could thus be detected in each child. When children with and without scoliosis were compared, it became evident that scoliotic children grew faster. Girls whose scoliosis developed from a previously normal body posture showed a peak height velocity (PHV) of 8.1 cm per year, whereas girls with a normal body posture throughout the pubertal stage had a PHV of 7.1 cm per year. The most rapid growth spurt was observed in Stages 2 and 3 of breast and pubic hair development. Simultaneously, the most frequent spinal status changes occurred in Stages 2 and 3 of sexual maturity; they were twice as frequent as in Stage 1 and four times as frequent as in Stages 4 and 5. Students in whom scoliosis developed in puberty during the adolescent growth spurt grew faster than their peers who did not develop scoliosis, which need not imply that they will eventually be taller after growth is completed.
- SourceAvailable from: Kevin B Jones[Show abstract] [Hide abstract]
ABSTRACT: Understanding the growth pattern in Marfan syndrome is important for prediction of expected growth, prevention of excessive growth by hormone therapy, timing of surgical epiphysiodesis for cessation of growth, and instituting brace treatment for scoliosis. In this study, we analyze growth patterns and generate growth charts for persons with Marfan syndrome. From the charts of 180 clinically diagnosed Marfan patients, longitudinal height and weight measurements were obtained. From this data, growth charts and growth velocity charts were generated for males and females. Skeletal maturation was studied by determining the Risser signs from the x-rays of 71 males and 56 females. From 22 female patients, age of menarche was available and retrieved either by reviewing the charts or contacting the patients. Mean length at birth was 53 +/- 4.4 cm for males and 52.5 +/- 3.5 cm for females. Mean final height was 191.3 +/- 9 cm for males and 175.4 +/- 8.2 cm for females. Mean birth weight was 3.51 +/- 0.74 kg for males and 3.48 +/- 0.68 kg for females. The puberty-associated peak in growth velocity was 2.4 years earlier than the gender-matched general population for males with Marfan syndrome and 2.2 years earlier for females. Age of menarche was 11.7 +/- 2 years of age, which is also early compared to the general population. This study suggests that the growth spurt and pubertal skeletal maturation occur early in Marfan syndrome. The growth curves generated should help more accurately predict adult stature, as well as monitor progression toward it.American Journal of Medical Genetics 04/2002; 109(2):100-15. DOI:10.1002/ajmg.10312 · 3.23 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The spinal growth in scoliotic segments (T4-L4) of 110 girls with untreated idiopathic scoliosis was measured from two successive radiographs taken at a mean interval of 1.1 years. At the first visit the mean age of the patients was 14 years (range 11–16 years), the mean magnitude of the major curves 24 (range 9–38) and that of the minor curves 14 (range 2–38). Spinal growth was most rapid at the age of 11–12 years. The progression of the curves (major plus minor) correlated with the spinal growth (r=0.384). The greater the initial curves were, the stronger the correlation was between the spinal growth and the progression of the curves (r=0.046–0.639), and the correlation was more significant in thoracic scoliosis (r=0.560) than in thoracolumbar and lumbar scoliosis (r=0.152).Le dveloppement rachidien dans les segments scoliotiques (Th4-L4) chez 110 jeunes filles prsentant une scoliose idiopathique non traite, a t valu d'aprs deux radiographies successives espaces en moyenne de 1.1 anne. Lors du premier examen, l'ge moyen des patients tait de 14 ans (11–16), la valuer angulaire myoenne des courbures majeures tait de 24 degrs (9–38) et celle des courbures mineures de 14 degrs (2–38). La croissance rachidienne atteignait sa valeur maximale l'ge de 11–12 ans. La progression des courbures (majeure+mineure) a t corrle la croissance rachidienne (r=0.384). La corrlation entre la croissance rachidienne et la progression des courbures taient plus importante que les courbures initiales taient plus prononces (r=0.046–0.639). Cette corrlation s'est montre plus significative dans les scolioses thoraciques (r=0.560) que dans les scolioses thoraco-lombaires et lombaires (r=0.152).European Spine Journal 02/1993; 1(4):236-239. DOI:10.1007/BF00298366 · 2.47 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The aetiology of idiopathic scoliosis: biomechanical and neuromuscular factors small curve develops due to a small defect in the neuromuscular control system and a second stage during adolescent growth in which the scoliotic curve is exacerbated by biomechanical factors.European Spine Journal 07/2000; 9(3):178-84. DOI:10.1007/s005860000142 · 2.47 Impact Factor