Article

Abnormal permeability precedes the development of a gluten sensitive enteropathy in Irish setter dogs.

Department of Veterinary Pathology, University of Liverpool.
Gut (Impact Factor: 13.32). 08/1991; 32(7):749-53. DOI: 10.1136/gut.32.7.749
Source: PubMed

ABSTRACT Intestinal permeability to 51Cr-EDTA was examined during the development of gluten sensitive enteropathy in dogs bred from affected Irish setters and reared on a normal wheat containing diet. Comparisons were made with litter mates reared on a gluten free diet and with a control group of age matched, clinically healthy Irish setters reared on the normal diet. Studies at 4, 6, 8, and 12 months of age were correlated with morphometric and biochemical examinations of peroral jejunal biopsy specimens. Permeability was increased at all ages in the group fed gluten free diet compared with control dogs, although there were no differences in villus height, intraepithelial lymphocyte density, and alkaline phosphatase activity. At four months, permeability in the normal diet group was greater than in controls, although comparable with that in the gluten free diet group. Permeability in the normal diet group increased further in conjunction with the development of partial villus atrophy and reduced alkaline phosphatase activity, and by 12 months permeability was significantly greater than in their gluten free diet litter mates and the control dogs. The findings suggest that an underlying permeability abnormality may be involved in the pathogenesis of gluten sensitive enteropathy in Irish setter dogs.

Full-text

Available from: Roger Batt, Jul 09, 2014
0 Followers
 · 
65 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: La maladie cœliaque est une maladie auto-immune qui atteint d’une façon prédominante les intestins chez les individus qui sont génétiquement prédisposés suite à l’ingestion d’aliments contenant du gluten. La maladie cœliaque peut être associée à plusieurs manifestations telles que l’anémie ferriprive, la dermatite herpétiforme, le déficit sélectif en IgA, une atteinte thyroïdienne et le diabète de type I. Cependant, l’association de la maladie cœliaque avec la cardiomyopathie dilatée, bien que décrite, est moins bien connue. Nous décrivons le cas d’un patient atteint de cardiomyopathie dilatée chez qui un bilan immunologique a montré des anomalies sérologiques en faveur de la maladie cœliaque. Ce patient n’avait jamais présenté de signe clinique en faveur de la maladie cœliaque. La mise du malade sous régime sans gluten a permis d’améliorer sa fonction cardiaque.
    Immuno-analyse & Biologie Spécialisée 08/2012; 27(4):191–194. DOI:10.1016/j.immbio.2012.05.005 · 0.11 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Food allergy in dogs and cats, although rare, is a well recognised cause of skin disease. However, despite reports of conditions responding to dietary manipulation, evidence for gastrointestinal manifestations of food allergy is scarce. Difficulties involved in reaching a clinical diagnosis of food allergy are discussed in an attempt to explain this enigma. The distinction between food allergy and intolerance, the complexity of the gastrointestinal immune system and the limited understanding of the mechanisms by which food allergy develops are reviewed.
    Journal of Small Animal Practice 06/2008; 35(3):145 - 152. DOI:10.1111/j.1748-5827.1994.tb03919.x · 0.91 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Transport of molecules across the intestinal epithelium takes place through 2 major routes, ie, trans-cellular and paracellular. Assessment of intestinal permeability is performed to assess the overall function of transport through the intestinal epithelial paracellular route. Urinary excretion of disaccharides and monosaccharides and ratio of their excretion is a basis for measurement of intestinal permeability. Lactulose and mannitol ratio is the most commonly used test for assessment of small intestinal permeability and the most reliable method for measurement of concentration of lactulose and mannitol in the urine is high performance liquid chromatography. After the measurement of concentration of probes in the urine; the results are expressed as the ratio of percentage excretion of the ingested dose of lactulose and mannitol in the urine. Testing of intestinal permeability is not required for routine patient care, however it is an important tool to understand the function of the paracellular transport in the research setting. Increase in intestinal permeability has been implicated in the pathogenesis of many autoimmune diseases including celiac disease, Crohn's disease, type I diabetes and food allergy.
    Journal of neurogastroenterology and motility 10/2012; 18(4):443-7. DOI:10.5056/jnm.2012.18.4.443 · 2.70 Impact Factor