Article

Neural transplantation (auto-adrenal, fetal nigral and fetal adrenal) in Parkinson's disease: the Mexican experience.

Department of Neurosurgery, Centro Medico La Raza, Mexico City, Mexico.
Progress in brain research (Impact Factor: 5.1). 02/1990; 82:593-602.
Source: PubMed
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    ABSTRACT: The pathological hallmark of Parkinson�s disease is a gradual loss of nigrostriatal dopamine-containing neurons, which is responsible for the cardinal motor symptoms of the disease. Current therapeutic strategies are mostly based on pharmacological enhancement of dopaminergic neurotransmission. This therapeutic approach has several long-term side effects, such as dyskinesias and fl uctuations of response, and is therefore limited in its use. Transplantation of fetal dopaminergic precursor cells has provided the proof that a cell replacement therapy can ameliorate clinical symptoms in affected patients. Novel therapies aiming at a stimulation of an endogenous dopamine production within the brain at a continuous rate might provide a more physiological and elegant way to overcome the dopaminergic defi ciency in parkinsonian brains. This article will review recent studies demonstrating the potential of these alternative cell graft sources for treating Parkinson�s disease. En la enfermedad de Parkinson, las neuronas dopaminérgicas de la sustancia nigra degeneran, lo que trae como consecuencia un défi cit de dopamina en sus áreas de proyección. Estas alteraciones histológicas y neuroquímicas se traducen en la mayoría de los trastornos motores que presentan los pacientes parkinsonianos. Las estrategias terapéuticas actuales se basan en fármacos que mejoran la neurotransmisión dopaminergica. Este enfoque terapéutico tiene efectos secundarios a largo plazo, como fl uctuaciones de la respuesta motora y discinesias. El trasplante de células dopaminérgicas fetales ha demostrado una mejoría de los síntomas clínicos. Actualmente, se desarrollan nuevas estrategias terapéuticas para estimular un reemplazo neuronal endógeno a partir de precursores neuronales presentes en el cerebro adulto. Este trabajo resume los estudios que muestran el potencial de la terapia celular en la enfermedad de Parkinson.
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