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Available from: Michael Sharpe, Mar 12, 2014
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    • "The SF-36 is a short form self-report measure on functional status related to health [23]. The SF-36 assesses functioning on eight subscales including domains of physical functioning, role physical, bodily pain, general health, social functioning, vitality, role emotional, and mental health on a 0-100 scale, where a higher score indicates better functioning. "
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    ABSTRACT: Few studies have compared symptomatology and functional differences experienced by patients with chronic fatigue syndrome (CFS) across cultures. The current study compared patients with CFS from the United States (US) to those from the United Kingdom (UK) across areas of functioning, symptomatology, and illness onset characteristics. Individuals in each sample met criteria for CFS as defined by Fukuda et al. (1994). These samples were compared on two measures of disability and impairment, the DePaul Symptom Questionnarie (DSQ) and the Medical outcomes study 36-item short-form health survey (SF-36). Results revealed that the UK sample was significantly more impaired in terms of mental health and role emotional functioning, as well as specific symptoms of pain, neurocognitive difficulties, and immune manifestations. In addition, the UK sample was more likely to be working rather than on disability. Individuals in the US sample reported more difficulties falling asleep, more frequently reported experiencing a sudden illness onset (within 24 hours), and more often reported that the cause of illness was primarily due to physical causes. These findings suggest that there may be important differences in illness characteristics across individuals with CFS in the US and the UK, and this has implications for the comparability of research findings across these two countries.
    10/2015; 2015(52):98-107. DOI:10.5923/j.ijpbs.20150502.07
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    • "One hundred and twenty-four patients (95 female and 29 male) referred to the Fatigue Service at the Royal Free London NHS Foundation Trust, UK, were recruited for the purposes of this study. All patients were given a formal diagnosis of CFS according to the Oxford Criteria (Sharpe et al., 1991). The self-reported mean time since the onset of symptoms was 9.1 years (range 1–45). "
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    ABSTRACT: Objective: This paper presents the development and preliminary validation of a self-report instrument designed to measure metacognitions pertaining to symptoms control in the form of the following: (1) symptoms focusing and (2) symptoms conceptual thinking.Methods: A total of 124 patients (95 female and 29 male) presenting with chronic fatigue syndrome (CFS) contributed data to the study to test the structure and psychometric properties of the Metacognitions about Symptoms Control Scale (MaSCS).Results: A principal components factor analysis indicated that a two-factor solution best fitted the data. The factors were labelled positive and negative metacognitions about symptoms control. Further analyses revealed that both factors had good internal consistency. Correlation analyses established preliminary concurrent validity, indicating that both positive and negative metacognitions about symptoms control were significantly associated with levels of fatigue in CFS. Regression analysis revealed that positive and negative metacognitions about symptoms control significantly predicted fatigue severity when controlling for anxiety and depression.Conclusions: The newly developed instrument may help future research that examines the role of metacognitions in CFS, as well as aiding clinical assessment and case formulation.
    Clinical Psychology & Psychotherapy 09/2015; 22(5):443-449. DOI:10.1002/cpp.1906 · 2.59 Impact Factor
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    • "The mean age of patients was 40.8 years (SD = 12.5; range 18-75). Patients with a diagnosis of CFS according to the Oxford Criteria (Sharpe et al., 1991) were included in this study. Table 1 shows fatigue, physical functioning, anxiety, and depression baseline scores for CBT and GET patients. "
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    ABSTRACT: Studies have reported that Cognitive Behavioural Therapy (CBT) and Graded Exercise Therapy (GET) are effective treatments for Chronic Fatigue Syndrome (CFS). One hundred and seventy-one patients undertook a course of either CBT (n = 116) or GET (n = 55) and were assessed on a variety of self-report measures at pre- and posttreatment and follow-up. In this paper we present analyses on treatment outcomes for CBT and GET in routine clinical practice and evaluate whether changes on subscales of the Metacognitions Questionnaire-30 (MCQ-30) predict fatigue severity independently of changes in other covariates, and across the two treatment modalities. Both CBT and GET were equally effective at decreasing fatigue, anxiety, and depression, and at increasing physical functioning. Changes on the subscales of the MCQ-30 were also found to have a significant effect on fatigue severity independently of changes in other covariates and across treatment modalities. The findings from the current study suggest that CFS treatment protocols for CBT and GET, based on those from the PACE trial, achieve similar to poorer outcomes in routine clinical practice as in a RCT.
    Behavioural and Cognitive Psychotherapy 04/2015; in press. DOI:10.1017/S135246581500017X · 1.69 Impact Factor
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