To evaluate type 1 hypersensitivity to reactive dyes, its prevalence, and its relationship to respiratory dysfunction, we studied clinical and immunologic features, including skin prick tests. RAST, and bronchoprovocation tests, of 309 employees working in a reactive-dye industry. Our survey revealed that 78 (25.2%) employees had work-related lower respiratory symptoms associated with or without nasal, skin, or eye symptoms. Among these employees, 38 (48.7%) had nonspecific bronchial reactivity. Thirteen demonstrated immediate (6), dual (6), or late only (1) asthmatic responses after inhalation of four kinds of reactive-dye solutions. Twenty-five employees demonstrated immediate skin responses to black GR dye, and 21 reacted to orange 3R. Fifty-three employees (17%) had specific serum IgE antibody against black GR and orange 3R-human serum albumin conjugate. Specific IgE was detected more frequently in symptomatic employees (30%) and smokers (100%). No association was found between atopy and specific IgE binding. The RAST-inhibition tests of black GR revealed significant inhibitions by black GR-human serum albumin conjugate and minimal inhibitions by unconjugated black GR. Orange 3R RAST-inhibition tests revealed significant inhibitions by conjugated forms of black GR and orange 3R and some inhibitions by two unconjugated dyes, suggesting an immunologic cross-reactivity between these dyes. These findings suggested that reactive dyes could induce immunologic responses, most likely IgE-mediated.
"Allergic dermatoses and respiratory diseases are known to be caused by reactive dyes (Hatch and Maibach 1995; Manzini et al. 1996). Contact dermatitis, asthma (Thoren et al. 1980) and immunosensitivity (Park et al. 1991) have been reported in textile industry workers exposed to dyes. Previous studies have also suggested increased risks of colon and rectum cancers; however, these cancers relate mostly to dyes for synthetic fibres (De Roos et al. 2005). "
[Show abstract][Hide abstract] ABSTRACT: Environment damages by pollutants from various sources have become a very serious predicament posing grave threats to mankind, plant wealth and other life forms. It is a challenging and daunting task to overcome this problem for which various physical, chemical and biological remedies have been followed successfully in some cases. Among the biological sources, research focused on plants has generated promising results for establishing an inexpensive, safe and economically viable technology. Several plants of diverse origin have been exploited rewardingly for converting perilous compounds into harmless and less dangerous products. The present review describes mainly three pollutants from textile dyes, paint preservative and heavy metal contaminants which are having carcinogenic and other life threatening properties. Role of plants has been demonstrated convincingly in several examples for removal of toxic chemicals from the environment. Recently, plant biotechnology has opened up new avenues for phytoremediation research offering numerous advantages for determining precise and accurate process of remediation of pollutants under controlled experimental conditions. This overview is an attempt to present a concise description of research currently underway on phytoremediation.
Journal of Plant Biochemistry and Biotechnology 04/2013; 23(2). DOI:10.1007/s13562-013-0250-6 · 1.09 Impact Factor
"RDs were among the most frequent causes of OA in Korea until the 1990s.6 Of these dyes, Black GR is the most frequent sensitizer; others include Orange 3R, Blue GG, and Green 6B.4,7,8 There has been no previous report of OA caused by Synozol Red-K 3BS (Red-K). "
[Show abstract][Hide abstract] ABSTRACT: Various reactive dyes can elicit occupational asthma in exposed textile industry workers. To date, there has been no report of occupational asthma caused by the red dye Synozol Red-K 3BS (Red-K). Here, we report a 38-year-old male textile worker with occupational asthma and rhinitis induced by inhalation of Red-K. He showed positive responses to Red-K extract on skin-prick testing and serum specific IgE antibodies to Red-K-human serum albumin conjugate were detected using an enzyme-linked immunosorbent assay. A bronchoprovocation test with Red-K extract resulted in significant bronchoconstriction. These findings suggest that the inhalation of the reactive dye Red-K can induce IgE-mediated occupational asthma and rhinitis in exposed workers.
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