Article

Characterization of the ADP-ribosylation of actin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.

Rudolf-Buchheim Institut für Pharmakologie, Universität Giessen.
Journal de physiologie 02/1990; 84(4):262-6.
Source: PubMed

ABSTRACT Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin belong to a novel family of actin ADP-ribosylating toxins. ADP-ribosylation of actin inhibits actin polymerization and G-actin-associated ATPase activity. The ADP-form of actin is ADP-ribosylated at a higher rate than actin with bound ATP. ADP-ribosylation of actin is reversible, a reaction, which is accompanied by reconstitution of actin ATPase activity.

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Keywords

actin
 
actin ADP-ribosylating toxins
 
actin ATPase activity
 
actin inhibits actin polymerization
 
Clostridium botulinum C2 toxin
 
Clostridium perfringens iota toxin
 
G-actin-associated ATPase activity
 
higher rate
 
novel family
 
reconstitution
 

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