Article

Thin-layer chromatography and densitometry in drug assay: comparison of methods for monitoring valproic acid in plasma.

Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Italy.
Journal of Pharmaceutical and Biomedical Analysis (impact factor: 2.97). 02/1990; 8(5):431-6. DOI:10.1016/0731-7085(90)80071-V
Source: PubMed

ABSTRACT A thin-layer chromatographic (TLC) method is described for the assay of the anti-epileptic drug, valproic acid, in plasma. The use of high-performance (HPTLC) plates gave sensitive detection limits (4.87 micrograms ml-1) for derivatives of valproic acid and the reproducibility on the same or different plates was good. Comparison with high-performance liquid chromatography showed a similar performance of plate and column.

0 0
 · 
0 Bookmarks
 · 
16 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

anti-epileptic drug
 
different plates
 
high-performance
 
high-performance liquid chromatography
 
HPTLC
 
reproducibility
 
sensitive detection limits
 
similar performance
 
TLC
 

P Corti