Conference Paper

Study the Biological Activities of Tribulus Terrestris Extracts

Conference: World Academy of Science, Engineering and Technology 57 2009

ABSTRACT In this study the extracts of the Iraqi herb Tribulus
terrestris (Al-Hassage or Al-Kutub) was done by using of polar and
non polar solvents, then the biological activity of these extractants
was studied in three fields, First, the antibacterial activity (in vitro)
on gram positive bacteria (Staphylococcus aureus), and gram
negative bacteria (E. coli, Proteus vulgaris, Pseudomonas
aerugiuosa, and Klebsiella), all extracts showed considerable activity
against all bacteria. Second, the effect of extracts on free serum
testosterone level in male mice (in vivo), the alcoholic, and
acetonitrilic extracts showed significant (P < 0.05) increase in free
serum testosterone level, and we found that the extracts contained
compounds with less genotoxic effects in mice germ cells. 3rd, was to
study the effect of methanolic extract of T. terrestris in diabetes
management.

0 Bookmarks
 · 
215 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: The antimicrobial and antioxidant activities of quinazolinones have widely been studied. However, there have been no studies on the antimicrobial and antioxidant activities of synthetic quinazolinones derived from anthranilic acid. The antimicrobial activities of newly synthesized compounds against a number of medically relevant bacteria and fungi were investigated. In addition, the free-radical scavenging activities of these compounds were measured using the 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, and nitroxyl radical assays and were compared with the activity of ascorbic acid. All compounds exhibited significant antimicrobial activity. In addition, these compounds were found to be superior to ascorbic acid in terms of their antioxidant activities. Theoretical calculations of the synthesized compounds were performed using molecular structures with optimized geometries. The molecular orbital calculations provide a detailed description of the orbitals, including the spatial characteristics, nodal patterns, and the contributions of individual atoms. The energies of the highest occupied molecular orbital and the lowest unoccupied molecular orbital and the structures of the compounds are shown.
    Medicinal Chemistry Research 01/2014; · 1.61 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Newly synthesized coumarins 4-((5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-methoxy)-2H-chromen-2-one and 4-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)-methoxy)-2H-chromen-2-one were tested against selected types of fungi and showed significant activities. DFT calculations of the synthesized coumarins were performed using molecular structures with optimized geometries. Molecular orbital calculations provide a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms.
    Molecules 01/2012; 17(5):5713-23. · 2.43 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: (E)-3-((5-phenyl-1,3,4-oxadiazol-2-ylimino)methyl)naphthalen-2-ol (LH) has been synthesized and used as a ligand for the formation of V(IV), Cr(III), Mn(II), Co(II), Ni(II), and Cu(II) complexes. The chemical structures were characterized using different spectroscopic methods. The elemental analyses revealed that the complexes have the general formula [ML2(H2O)2] [where M = Mn(II), Co(II), and Cu(II)], while the Cr(III) complex has the formula [CrL2(H2O)2]Cl, V(IV) complex has the formula [VO2L2], and Ni(II) complex has the formula [NiL2]. The molar conductance data revealed that all the metal chelates except the Cr(III) are non-electrolytes. From the magnetic susceptibility measurement and UV–Visible spectra, it is found that the structures of Cr(III), Mn(II), Co(II), and Cu(II) complexes are octahedral, V(IV), complex is square pyramid and Ni(II) complex is square planar. The stability of the prepared complexes was studied theoretically using density function theory. The total energy for the complexes was calculated and it was shown that the copper complex is the most stable. Complexes were tested against selected types of microbial organisms and showed significant activities. The free radical scavenging activity of metal complexes have been determined by their interaction with the stable DPPH-free radicals. All the compounds have shown encouraging antioxidant activities.
    Medicinal Chemistry Research 21(10). · 1.61 Impact Factor

Full-text

Download
258 Downloads
Available from
Jun 4, 2014