Activation of D1 dopamine receptors stimulates the release of GABA in the basal ganglia
Department of Physiology, Biophysics and Neurosciences, Instituto Politecnico Nacional, Mexico, D.F. Neuroscience Letters
(Impact Factor: 2.03).
09/1990; 116(1-2):136-40. DOI: 10.1016/0304-3940(90)90399-T
Here we have explored whether dopamine is able to modulate the release of gamma-aminobutyric acid (GABA) from striatal terminals to substantia nigra pars reticulata, entopeduncular nucleus, globus pallidus and caudate-putamen. The type of dopamine receptors involved was assessed by the blocking effect of either SCH 23390 (D1 antagonist) or (-)-sulpiride (D2 antagonist) of the dopamine effect. Dopamine stimulated (EC50 3.2 microM) the depolarization-induced release of [3H]GABA from slices isolated from all of the above mentioned nuclei. SCH 23390 dose-dependently blocked the dopamine stimulation, but (-)-sulpiride did not show any blocking effect. The results suggest that dopamine via D1 receptors modulates the release of GABA from striatal GABAergic terminals.
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