Long-term abstinence from alcohol in patients receiving aversion therapy as part of a multimodal inpatient program.
ABSTRACT A sample of 200 patients who had been treated for alcoholism in a multimodal inpatient program that used aversion therapy as a treatment component was selected for outcome evaluation. One hundred sixty (80%) were located. A minimum of 13 months had elapsed since treatment (mean 20.5 months) collateral reports were used to verify self-reports in 36% of the cases. Abstinence status was determined for the first 12 months since treatment, the entire elapsed time since treatment (range 13 to 25 months, mean 20.5 months), and "current abstinence" (last 6 months). The abstinence rate for the first 12 months was 71.3%; for the total period since treatment, the rate was 65% (mean 20.5 months); the current abstinence rate was 78.1%. The data was also viewed from other perspectives. The findings of this study suggest that a multimodal alcoholism treatment program utilizing aversion conditioning is at least as acceptable to patients as counseling centered programs and can be expected to yield favorable abstinence rates.
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ABSTRACT: Eighty-two hospitalized alcoholics receiving pharmacological aversion therapy (PAT) over a 10-day treatment interval completed cognitive, behavioral, and psychophysiological measures evaluating conditioned aversion to alcohol. Pre-post assessments provided convergent support for the efficacy of PAT vis-à-vis production of conditioned aversion to alcohol. Positive alcoholrelated outcome expectancies were significantly reduced, whereas confidence that drinking could be avoided in various high-risk situations for consumption was increased following PAT. Behavioral and cardiac rate assessments revealed significant changes following PAT that were specific to alcoholic beverages and potentially reflective of conditioned alcohol aversion. Patients with more extensive pretreatment experiences with alcohol-associated nausea and greater involvement in antisocial conduct appeared to be less susceptible to the PAT conditioning protocol.The American Journal of Drug and Alcohol Abuse 07/2009; 27(3). · 1.47 Impact Factor
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ABSTRACT: There is a paucity of research on pharmacotherapies in adolescents with substance use disorders. This paucity is partly because of the fact that most people with substance dependence do not get diagnosed until early adulthood, that is, after 18 years of age. This article reviews pharmacotherapies used for aversion, substitution, anti-craving, and detoxification of alcohol, nicotine, cocaine, and opioids dependence. Adult research is referenced when applicable and generalized to adolescents with caution. Continued evaluation and development of pharmacotherapy for youth in controlled studies are needed to examine medication effectiveness, safety, potential for abuse, compliance, and potential interactions with other medications or substances of abuse.Child and adolescent psychiatric clinics of North America 07/2010; 19(3):591-608. · 2.88 Impact Factor
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ABSTRACT: Virtual reality (VR) is an evolving technology that is being applied to treat a wide range of medical and psychiatric diseases. A virtual reality therapy (VRT) with multisensory stimulation has been applied to patients with alcohol dependence (ADP). We hypothesized that the VRTP for alcohol dependence would reduce the craving for alcohol and increase alpha wave activity in frontal areas of individuals with ADP. Twenty ADP and eighteen ADP were exposed to a series of 10 VRTP sessions (VRTP-ADP) and cognitive behavioral therapy (nVRTP-ADP), respectively. Fifteen healthy controls were exposed to VRTP for comparing the changes of craving and EEG during all three phases of VRTP. The VRTP-ADP exhibited a greater decrease in craving after the 10th VRTP session, when compared to the nVRTP-ADP. Compared to the healthy control subjects, VRTP-ADP group showed higher magnitude of the change in craving throughout VRTP sessions. These results suggest that VRTP may be useful as an adjunct to treating alcohol dependence but may also serve as an evaluation tool to identify high-risk patients.Pharmacology Biochemistry and Behavior 09/2008; 91(3):393-7. · 2.82 Impact Factor
Long-Term Abstinence From Alcohol in Patients Receiving
Aversion Therapy as Part of a Multimodal Inpatient Program
Journal of Substance Abuse Treatment, Vol. 7, pp. 77-82, 1990
Printed in the USA. All rights reserved.
Copyright © 1990 Pergamon Press Ltd.
James W. Smith, MD, and P. Joseph Frawley, MD
Schick Health Services, Seattle, Washington, and Schick Shadel Hospital, Santa Barbara, California
A sample of 200 patients who had been treated for alcoholism in a multimodal inpatient program that used aversion
therapy as a treatment component was selected for outcome evaluation. One hundred sixty (80%) were located. A
minimum of 13 months had elapsed since treatment (mean 20.5 months) collateral reports were used to verify self-reports
in 36% of the cases. Abstinence status was determined for the first 12 months since treatment, the entire elapsed time
since treatment (range 13 to 25 months, mean 20.5 months), and "current abstinence" (last 6 months). The abstinence
rate for the first 12 months was 71.3%; for the total period since treatment, the rate was 65% (mean 20.5 months); the
current abstinence rate was 78.1%. The data was also viewed from other perspectives. The findings of this study suggest
that a multimodal alcoholism treatment program utilizing aversion conditioning is at least as acceptable to patients as
counseling centered programs and can be expected to yield favorable abstinence rates.
Keywords: Alcoholism treatment, abstinence, aversion therapy, treatment outcome, inpatient treatment
In order to evaluate the appropriateness and effectiveness of treatment for any disease, the basic evaluative tool is
the outcome study. The field of alcoholism treatment has come under criticism because of a general lack of such
studies and the relatively poor quality of those studies that have been carried out. Critics have pointed out the
anecdotal nature of many reports, the lack of control groups, and the lack of blind procedures (Nathan & Skinstad,
1987; Sobell, Brochu, Sobel, Roy, & Stevens, 1987).
Some of these deficiencies are inherent in the nature of the treatment process (e.g., it is inherently impossible to
have a double blind study when one component of treatment is aversion therapy). Other difficulties arise when
attempting to assess results from programs where the treatment goal is difficult to quantitate or measure (e.g.,
"recovery" or "sobriety").
It is even more difficult to compare the results of treatment carried out in different centers when there is a lack of
agreement on the desired outcome (e.g., "controlled drinking" versus abstinence from alcohol versus abstinence
(from all mood altering drugs).
Nevertheless, it is the belief of the authors that it is the duty of responsible treatment programs to carry out
periodic assessments of their treatment outcomes and that results should be made available to other professionals
in the field. Schick Shadel Hospitals have conducted outcome research since their founding in 1935, and the early
development and treatment team of Voegtlin and Lemere are widely quoted as among the first in the United States
to publish such data (Voegtlin, 1940; Lemere & Voegtlin, 1940; Voegtlin, Lemere, & Broz, 1948). The present
study is a continuation of this process of periodic analysis of treatment outcome at Schick Shadel Hospitals.
The objective was to determine the alcohol abstinence rate of patients treated for the first time at Schick Shadel
Hospital of Santa Barbara, California, at least one year after treatment. A random sample of 200 patients who
had completed the initial 10 days of treatment at that hospital in 1983 was selected. The total number of patients
who met these criteria that year was 377. The selection process was as follows: Using a list of random numbers,
200 two-digit numbers were selected. These random numbers were matched with the last two digits of the
case numbers of patients treated in 1983. Those cases matched in this manner were selected for follow-up. The
sampling method insured that every patient treated at the hospital in 1983 had an equal chance of being selected
for follow-up. No patient completing the initial 10 days of treatment was included or excluded from the study for
any reason except chance.
Each patient was then telephoned by a trained interviewer employed by the independent research organization
conducting the study (Facts Consolidated of Los Angeles, California). Each interviewer was first indoctrinated in
the applicable statutes and policies concerning confidentiality as they apply to patients of an alcoholism treatment
Patients were systematically telephoned until contact was made or until all possibilities of locating them by phone
had been exhausted. Those contacted received a structured interview. In cases where pursuance of the interview
would cause a breach of confidentiality, further attempts to reach that patient were abandoned. Using this
procedure, 160 patients were successfully interviewed and 40 were not (80% personal contact rate).
A sample of 160 patients selected in this manner has a margin for statistical error of 7.9% at the .95 confidence
level. That is, the chances are 95 out of 100 that the results that were obtained would not differ more than 7.9%
in either direction from the results obtained from another similar group of 1983 patients treated at Schick Shadel
In addition to patient interviews, a verification interview with a significant other was carried out in 36% of
cases (58 interviews). In only one case did the verification interview give results that conflicted with the patient’s
response. In that case the patient outcome category was changed from abstinent to non-abstinent.
In instances where the patient reported abstinence from the time of treatment to the 12 month mark, but also
reported relapse after 12 months, verification of that report was obtained in 100% of the cases. In this group, only
those cases where the significant other verified continuous abstinence through 12 months were included in the 12
months abstinent category.
In addition to the 160 patients whose status was determined by this interviewing procedure, 5 were decreased and
5 refused to be interviewed. These 10 patients were listed in the no contact group.
In addition to the telephone contacts, the charts of all 200 patients were reviewed. The chart-documented status
of the 40 patients who were not contacted was also incorporated into the data for analysis. Those with a chart-
documented relapse were placed in the relapse group. This gave the opportunity to look at the data three ways:
1. Analysis of the data on the 160 contacted patients (80% follow-up).
2. Analysis of the data on the 160 contacted patients plus the non-contacted patients with chart-documented
relapse (n = 22) for a total of 182 cases (91% follow-up).
3. Analysis of data on all 200 patients (100%).
The outcome survey was conducted in February and March 1985. A minimum of 13 months and as many as 25
months had elapsed since the completion of treatment (mean 20.5 months).
The Treatment Program
The treatment program of Schick Shadel Hospital is described in more detail elsewhere (Smith, 1982). Briefly, it
1. A detailed medical evaluation (including laboratory studies).
2. Medical detoxification for those who require it (approximately 50%).
3. Counseling (group and individual) for the patient and significant others. (Patients receive a detailed
psychosocial evaluation and a psychological evaluation).
4. Education on the addiction and recovery process for the patient and significant others.
5. A family program (individual and group).
6. Development of an aftercare plan with the patient and significant others (2-year plan).
7. Aversive counter-conditioning designed to make the sight, smell, taste, and thought of alcoholic beverages
unpalatable (Voegtlin, 1940; Cannon & Baker, 1981).
8. Narcotherapy (“pentothal interview”) designed to gather psychological diagnostic information in a short
period of time and also to monitor the development of aversion to the various alcoholic beverages by asking
about the level of desire for each type of beverage during each interview (Smith, Lemere, & Dunn, 1971).
9. Introduction to follow-up support activities such as 12-step programs, hospital-based support groups, and
The treatment program for the average patient is carried out during 10 days of hospitalization (post detoxification)
during which the patient receives five aversion treatments and five narcotherapy treatments. These two forms of
treatment are given on alternate days (e.g., Day 1 an aversion treatment, Day 2 a narcotherapy treatment). The
counseling and educational components of the program are carried out daily.
Following the initial 10 days of treatment, the patient returns home. He or she then returns to the hospital for two
2-day “reinforcement treatments,” usually at approximately 30 days and 90 days following their initial discharge.
These two-day hospitalizations include one aversion treatment and one narcotherapy treatment, again on an
alternate day basis. In addition, counseling and aftercare plan modification is carried out.
The goal of this treatment program is to assist each patient to regain control of his or her life through permanent
abstinence from alcohol. Abstinence from other potentially addictive drugs is also stressed. No aversion treatment
for drugs other than alcohol was available to this group of patients. The educational and counseling portion of the
program addressed this issue in those patients who were also using other drugs.
Those selected for interview were drawn from the universe of patients who had completed for the first time at
least the first 10 days (post detoxification) increment of the inpatient alcoholism treatment program at Schick
Shadel Hospital of Santa Barbara, California, during calendar year 1983. Only 3% of the patients admitted that
year left the hospital prior to completing the initial 10 day treatment program. Another 2.5% were admitted for
detoxification only. Neither group of patients were candidates for inclusion in this study.
The demographics of Schick Shadel Hospital patients have been described in detail elsewhere (Knowles, Smith,
& Lemere, 1983). Demographic details of the subjects of the present study are shown in Table 1. In general, they
resemble typical patients in other inpatient treatment programs for medically non-indigent persons (Weins &
Menustik, 1983; Cordill & Associates, 1988; Moberg, 1978). The majority were males (73%) between the ages of
25 and 55 (79.5%) and were married (61%). Almost all had at least a high school education (93.5%). Most (60%)
had at least some college education, and 23% had at least a bachelors degree. The majority (79%) were employed.
12 years (high school graduate)
Some college (but no degree)
Refused to answer
Other white collar
TABLE 1 - Demographics (N = 200)
All subjects met the DSM-III criteria for alcohol dependence. History of other drug use over the 6 months prior to
treatment was obtained (Table 2). Nearly 40% (39.6%) of the patients used some drug other than alcohol during
the six months prior to treatment. This use was limited to one drug in 14.3% of cases, two drugs in 15.4% of
cases, three drugs in 5.5% of cases, and four or more drugs in 3.8% of cases.
The types of other drugs used are shown in Table 3. Marijuana and cocaine were by far the most commonly used.
They were each used by 25.8% of patients. In many cases the same patient used both drugs.
Of this sample, 65% reported no previous formalized treatment of their alcohol dependence prior to treatment at
Schick Shadel Hospital, 13.8% had received previous inpatient treatment, 32.5% had received other formalized
treatment, and 41.9% reported participation in the fellowship of alcoholics anonymous.
Alcohol and other drug (s)
1 other drug
2 other drugs
3 other drugs
4 or more other drugs
Telephone contact group (N = 160)
Telephone contact plus chart-
documented relapses (N = 182)
Telephone contact plus chart-
documented relapse plus no chart-
documented relapse (N = 200)
Percent 13- to 25-month
Abstinence (Mean 20.5 mos)
No other drug use
Percent who used**
TABLE 2 - Drug(s) used in the 6 months prior to treatment (N = 200)
TABLE 4 - Abstinence Status
TABLE 3 - Drugs other than alcohol used in the 6 months prior to
* Patient population N = 182.
** Percentages add up to over 100% because some patients
used more than one drug.
Of the 200 patients selected for the study, 160 were contacted during the survey. The minimum elapsed time since
treatment was 13 months, and the maximum was 25 months (mean 20.5 months).
Information was obtained from these patients, with validating information from a significant other in 36% of cases.
The information obtained included:
1. Alcohol abstinence status over the entire span of time since treatment (total abstinence).
2. Alcohol abstinence status over the last six months (current abstinence).
3. Alcohol abstinence status over the first 12-month span of time following treatment (12-month abstinence).
Of the 40 patients who could not be contacted, chart review indicated that 22 of them were known to have
relapsed; 5 of these were known to be deceased. The remaining 18 had no indication of relapse documented in
The rate of abstinence at 12 months, 13-25 months (mean 20.5 months), and current abstinence (last 6 months)
is shown in Table 4. The contacted group (n = 160) comprised 80% of the 200 individuals selected for follow-up.
They had a 12-month abstinence rate of 71.3%, a 13-25 month (mean 20.5 month) abstinence rate of 65.0%, and
a current abstinent rate of 78.1%.
The group composed of contacted patients (n = 160) plus chart documented, relapsed, non-contacted patients (n
= 22) numbered 182 individuals (91% of the selected sample of 200). They had a 12-month abstinence rate of
62.6%, a 13-25 month (mean 20.5 month) abstinent rate of 57.1%).
The total group of 200 individuals (100% sample) composed of contacted individuals (n = 160), chart documented
relapsed, non-contacted patients (n = 22), and non-contacted patients without chart evidence of relapse (n = 18)
had abstinence rates of 66.5% at 12 months and 61.5% at 13-25 months (mean 20.5 months).
Table 5 shows the patterns of alcohol consumption for the contacted group following treatment. It will be noted
that a few patients had one drink, or part of a drink, either deliberately or accidentally, after treatment. Although
these patients were not included in the total abstinence group, it can be reasonably concluded that they were
successful in achieving their treatment goal.
No alcohol for at least 12 months
No alcohol since treatment (mean 20.5 mo.)
Accidental consumption, once only, abstinent since then
Deliberate consumption, once only, abstinent since then
Drank but abstinent 6 mo. or longer prior to follow-up
Drank but abstinent at follow-up less than 6 mo.
Still drinking at follow-up
TABLE 5 - Pattern of alcohol use of the contacted group after treatment (N = 160)
Of the 160 contacted patients, 61.3% were married at the time of admission. At the time of follow-up 77.6%
of these were still married, while 17.3% were divorced or separated. Of the 36 patients who were divorced or
separated at the time of admission, 7 (20%) were married at follow-up. Of the 22 who were single (never married)
at the time of admission, three (14%) were married at follow-up. Employment status was essentially unchanged.
The most powerful predictor of abstinence was the number of reinforcement treatments utilized by the patient.
Those taking the two regularly prescribed reinforcement treatments had a 12-month abstinent rate of 70.0%.
Those who took only one had a 44.0% 12-month abstinent rate, and those who had no reinforcements had
only a 27.0% abstinent rate. Of additional interest is the fact that the 7% of patients who took more than two
reinforcement treatments had a 12 month abstinent rate of 92%.
Although authorities in the field of alcoholism treatment are not unanimous in choosing total abstinence from
alcohol as the ultimate goal (Nathan & Skinstad, 1987), abstinence has been the traditional goal of the Schick
Shadel program since its beginning in 1935. The authors readily agree that an enhanced quality of all aspects of
life for the patient and family is the ultimate goal. However, it is our opinion that this goal is most often reached
by alcoholics after they become abstinent. Babor, Dolinsky, Rounsaville, and Jaffe (1988) showed a clear linear
relationship between the level of alcohol consumption post treatment and failure to improve in medical status,
biological function, and psychopathology. Emrick (1974) reviewed 110 studies and found over two-thirds of the
outcome criteria improved as abstinence was achieved. In attempting to assess successful treatment outcome, the
end point of total abstinence is also much more easily measured and agreed upon than more subjective measures
such as “controlled drinking” or “enhanced quality of life.”
Abstinence status at a minimum of one year post treatment was chosen as an assessment point simply because
a majority of other outcome studies report results at this time. It therefore makes comparison of results more
convenient, although cogent arguments can, and have, been made for assessing outcome at shorter or longer
intervals (Costello, 1975a, 1975b; Emrick, 1975). Because of the high degree of mobility of people in the
United States where nearly one person out of five moves each year (U.S. Bureau of the Census, 1986) it becomes
extraordinarily difficult to locate persons after two, three, or more years. Therefore, one-year data seems to be a
reasonable compromise between the practical mechanics involved in conducting outcome studies and allowing
enough time to pass following treatment so that patients can demonstrate reasonable ability to live without alcohol.
The issue of relying on patient self-report on abstinence status has also been debated (Babor, Stephens, & Marlatt,
1987; Fuller, 1988; Watson, Tilleskjor, Hoodecheck-Schow, Pucel, & Jacobs, 1984; Maisto & O’Farrell, 1985;
Watson, 1985). A number of researchers have concluded that, so long as reports of drinking do not lead to
unwanted consequences, self reports of total abstinence are accurate (Sobell & Sobell, 1974; Sobell, Maisto, Sobell,
& Cooper, 1979; Babor et al., 1987). Some emphasize that self-reports on abstinence versus non-abstinence are
more accurate than self-reports on frequency and amounts consumed by those who are not abstinent (Sobell,
Sobell, & VanderSpek, 1979). Our own experience is consistent with both positions. We have found in past studies
that when collateral assessments of abstinence differ from patient reports, the difference is more likely to be in the
direction of the patient’s reporting a short period of drinking while the collateral reports continuous abstinence.
As a validity check in the present study, approximately one patient out of three (36%) had his or her abstinence
assessment compared to the assessment of a significant other. In only one case was there a disagreement. Therefore,
it again appears that self-report is sufficiently valid so that it represents a practical way of assessing abstinence rates
The fact that only 3% of patients left treatment before completing the initial 10 days (post detoxification) of
treatment suggests that, despite the use of aversion therapy, patient acceptance of the treatment program was
extremely high. Other treatment programs report premature discharge rates of 7% (Gilmore, 1985) to 21%
The goal of successfully achieving 12 months of continuous abstinence was achieved by the majority of patients. Of
the contacted group, 71.3% were successful. Even when a negatively biased view was taken (contacted group plus
non-contacted subjects with chart-documented relapse) the 12-month abstinence rate was 62.6%. These abstinence
rates compare favorably with those reported from other programs that are based primarily on counseling and group
therapy. Typical one year abstinence rates range from 31.9% to 59% (McLachlan, 1974; Freedberg & Johnston,
1981; Pettinati, Sugerman, DiDonato, & Maurer, 1982; Glatt & Lepzig, 1955; Gilmore, 1985).
The abstinence rates in this study are similar to, though somewhat higher than, those reported in the early days of
the Schick Shadel treatment program (e.g., 65.7% in the first study reported in 1940) (Voegtlin, 1940).
Taking both prescribed reinforcement treatment sessions was shown to be strongly associated with long-term
abstinence in this study. Wiens and Menustik (1983) reported similar findings in their outcome study, which also
used aversion therapy as a major treatment component.
Outcome studies on comparable patient populations conducted by other aversion conditioning programs also yield
high success rates, and are quite comparable to those reported from the early Schick Shadel studies (e.g., 52%
abstinence at one year reported by Neubuerger and colleagues (1982) and 63% one-year abstinence reported by
Weins and Menustik (1983).
These findings suggest that a multimodal alcoholism treatment program that also uses aversion therapy is at least as
acceptable to patients as counseling centered programs and can be expected to yield favorable abstinence rates.
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Requests for reprints should be addressed to, Research Director, Dr. Ralph Elkins, Schick Shadel Hospital,
12101 Ambaum Boulevard, SW, Seattle, WA 98146.