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Topography of movement-related cortical potentials is abnormal in Parkinson's disease.

I M Tarkka, J A Reilly, M Hallett

Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

Journal Article: Brain Research (impact factor: 2.46). 08/1990; 522(1):172-5.

Abstract

We studied the scalp-recorded, movement-related cortical potentials occurring immediately before and after the onset of movement in 5 patients with asymmetric Parkinson's disease. The topographic distribution of the initial slope of motor potential (isMP) was diffuse for voluntary finger movements of the more affected hand but normal for movements of the less affected hand. The frontal peak of motor potential (fpMP) was located more posterior in patients than in normal subjects. The peak amplitudes of the potentials were normal in all patients. The topographic abnormalities might reflect inadequate excitatory activity from the basal ganglia to the primary motor cortex and the supplementary motor area.

Source: PubMed

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Keywords

affected hand
 
asymmetric Parkinson's disease
 
basal ganglia
 
fpMP
 
frontal peak
 
inadequate excitatory activity
 
initial slope
 
motor potential
 
movement-related cortical potentials
 
movements
 
peak amplitudes
 
potentials
 
primary motor cortex
 
supplementary motor area
 
topographic abnormalities
 
topographic distribution
 
voluntary finger movements