Effects of heparin versus saline solution on intermittent infusion device irrigation
ABSTRACT The purpose of this study was to compare the effectiveness of 1 ml of 0.9% sodium chloride with 10 units of heparin in 1 ml sodium chloride solution, both containing benzyl alcohol, in maintaining patency and reducing the incidence of phlebitis in patients with intermittent infusion devices. The subjects (N = 32) were randomly assigned in a double-blind experimental design. Repeated-measures analysis of variance revealed no significant difference between the groups in phlebitis or patency variables. The results from this controlled study would suggest that 0.9% sodium chloride is as effective as 10 units of heparin in sodium chloride solution in maintaining intermittent infusion device patency and preventing phlebitis.
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ABSTRACT: The purpose of this prospective multi-site study was to determine the frequency of intravenous (IV) site symptoms and to develop a preliminary model of the factors implicated in the number of these symptoms. In a sample of 514 patients from four institutions, IV site symptoms including pain, redness, swelling, induration, and/or a venous cord were present in 205 (39.9%) of the patients. The IV catheters were in place an average of 48.7 hr. There were no significant differences in symptoms by hospital site. Using multiple regression techniques, a seven-factor model explained 18% of the variance in number of IV site symptoms. Further research is required to explore other potential causes for the numbers of IV site symptoms.Research in Nursing & Health 01/1991; 14(6):413-20. DOI:10.1002/nur.4770140605 · 1.27 Impact Factor
- Journal of Vascular Access Devices 12/1997; 2(2):16–18. DOI:10.2309/108300897778248648
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ABSTRACT: To evaluate the effect of heparin on duration of catheter patency and on prevention of complications associated with use of peripheral venous and arterial catheters. Critical appraisal and meta-analysis of 26 randomised controlled trials that evaluated infusion of heparin intermittently or continuously. Thirteen trials of peripheral venous catheters and two of peripheral arterial catheters met criteria for inclusion. Data on the populations, interventions, outcomes, and methodological quality. For peripheral venous catheters locked between use flushing with 10 U/ml of heparin instead of normal saline did not reduce the incidence of catheter clotting and phlebitis or improve catheter patency. When heparin was given as a continuous infusion at 1 U/ml the risk of phlebitis decreased (relative risk 0.55; 95% confidence interval 0.39 to 0.77), the duration of patency increased, and infusion failure was reduced (0.88; 0.72 to 1.07). Heparin significantly prolonged duration of patency of radial artery catheters and decreased the risk of clot formation (0.51; 0.42 to 0.61). Use of intermittent heparin flushes at doses of 10 U/ml in peripheral venous catheters locked between use had no benefit over normal saline flush. Infusion of low dose heparin through a peripheral arterial catheter prolonged the duration of patency but further study is needed to establish its benefit for peripheral venous catheters.BMJ Clinical Research 03/1998; 316(7136):969-75. DOI:10.1136/bmj.316.7136.969 · 14.09 Impact Factor