Effects of heparin versus saline solution on intermittent infusion device irrigation
Shawnee Mission Medical Center, Mission, KS 66201.Heart and Lung The Journal of Acute and Critical Care (Impact Factor: 1.29). 12/1990; 19(6):608-12.
The purpose of this study was to compare the effectiveness of 1 ml of 0.9% sodium chloride with 10 units of heparin in 1 ml sodium chloride solution, both containing benzyl alcohol, in maintaining patency and reducing the incidence of phlebitis in patients with intermittent infusion devices. The subjects (N = 32) were randomly assigned in a double-blind experimental design. Repeated-measures analysis of variance revealed no significant difference between the groups in phlebitis or patency variables. The results from this controlled study would suggest that 0.9% sodium chloride is as effective as 10 units of heparin in sodium chloride solution in maintaining intermittent infusion device patency and preventing phlebitis.
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ABSTRACT: The purpose of this prospective multi-site study was to determine the frequency of intravenous (IV) site symptoms and to develop a preliminary model of the factors implicated in the number of these symptoms. In a sample of 514 patients from four institutions, IV site symptoms including pain, redness, swelling, induration, and/or a venous cord were present in 205 (39.9%) of the patients. The IV catheters were in place an average of 48.7 hr. There were no significant differences in symptoms by hospital site. Using multiple regression techniques, a seven-factor model explained 18% of the variance in number of IV site symptoms. Further research is required to explore other potential causes for the numbers of IV site symptoms.Research in Nursing & Health 01/1991; 14(6):413-20. DOI:10.1002/nur.4770140605 · 1.27 Impact Factor
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ABSTRACT: The purpose of this meta-analysis was to estimate the effects of heparin flush and saline flush solutions on maintaining patency, preventing phlebitis, and increasing duration in peripheral heparin locks. The average effect size (d value) across 15 studies with a total sample size of 3,490 was .0573 for patency (clotting). The 95% credibility interval ranged from -.2267 to .3413. The average effect size across 13 studies with a total sample size of 2,356 was -.0757 for phlebitis. The 95% credibility interval ranged from -.2497 to .0983. The average effect size for duration across six samples with a total sample size of 1,960 was -.0550. The 95% credibility interval ranged from -.2424 to .1324. It can be concluded that saline is as effective as heparin in maintaining patency, preventing phlebitis, and increasing duration in peripheral intravenous locks. Quality of care can be enhanced by using saline as the flush solution, thereby eliminating problems associated with anticoagulant effects and drug incompatibilities. In addition, an estimated yearly savings of $109,100,000 to $218,200,000 U.S. health care dollars could be attained.Nursing Research 11/1991; 40(6):324-30. DOI:10.1097/00006199-199111000-00002 · 1.36 Impact Factor
- Annales Françaises d Anesthésie et de Réanimation 01/1995; 14(6):534-535. DOI:10.1016/S0750-7658(05)80501-5 · 0.84 Impact Factor
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