[Paradoxic effect of anti-T-2 toxin antibodies in the curative treatment of acute poisoning in mice].
ABSTRACT We have obtained polyclonal anti-T-2 toxin antibodies with high affinity to T-2 toxin (K = 0.34 x 10(9) l/M at 4 degrees C), crossreacting with HT-2 toxin, one of the major metabolites. We have assessed these antibodies in prevention and therapy of the acute intoxication. When given 24 h before 1 or 2 LD50 of T-2 toxin (5 or 10 mg/kg), the antibodies decreased the mortality from 67% to 37%, or from 100% to 83% respectively with an optimal antibody dosage of 100 mg/kg. In contrast when given 30 mn after the toxin, anti-T-2 toxin antibodies increased the mortality; in the same way non specific antibodies increased the mortality of mice intoxicated with T-2 toxin.