Correlation between conjunctival provocation test (CPT) and systemic allergometric tests in allergic conjunctivitis

Regional Centre for the Diagnosis and the Treatment of Inflammatory Eye Diseases, University of Padova, Italy.
Eye (Impact Factor: 2.08). 02/1990; 4 ( Pt 5)(5):760-4. DOI: 10.1038/eye.1990.109
Source: PubMed


In order to assess the potential usefulness of CPT as a diagnostic tool for ocular allergy, the correlation between skin/RAST tests and CPT was determined in 144 patients affected by allergic 'hay fever' type conjunctivitis. The results showed that an agreement between skin/RAST tests and CPT occurred in 71% of the cases (130/183). Of the 29% uncorrelated cases, 23% (43/183) were positive for at least one specific antigen by skin/RAST tests but not by CPT, while 6% (10/183) were positive for at least one specific antigen by CPT, but not by skin/RAST tests. CPT dramatically increased the histamine levels in tears (p less than 0.001). These findings show that (1) systemic tests can be misleading in that they may suggest a specific sensitisation which, in fact, does not involve the conjunctiva (systemic test positive/CPT negative); (2) CPT can identify local conjunctival sensitisation in the absence of a systemic sensitisation (systemic test negative/CPT positive); (3) CPT can demonstrate that allergic 'hay fever' type conjunctivitis may be related to allergens different from those responsible for a systemic sensitisation.

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Available from: Andrea Leonardi, Mar 11, 2014
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    • "In assessing the potential usefulness of CPTs as a diagnostic tool, it was found that CPTs directly correlated to the radioallergosorbent test (RAST) in 71% (n ¼ 130/183) of allergic patients. Of the 29% of uncorrelated cases, 23% (43/183) were positive by RAST but not by CPT, whereas 6% (10/183) were positive by CPT but not by RAST [30]. This finding suggests that there may be local sensitization of the target organ without evidence for systemic sensitization to the same antigen that clinically may reflect allergens causing ocular symptoms without any evidence of pulmonary or nasal allergic symptoms. "
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    Revue Française d Allergologie et d Immunologie Clinique 09/1996; 36(5):459-465. DOI:10.1016/S0335-7457(96)80003-7 · 0.24 Impact Factor
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