A study on the correlation of blood and vitreous humour alcohol levels in the late absorption and elimination phases.
ABSTRACT By using the urine:blood alcohol level ratio as the indicator, the correlation of blood alcohol level (B) and vitreous humour alcohol level (V) in the late absorption and elimination phases was studied. It was found to be good (r = 0.98) and B = 0.76V + 4.7. It is suggested that this equation can safely be used to estimate the minimum blood alcohol level where cadaveric blood is unsuitable or unavailable for analysis and that the B/V ratio can be used to infer the phase in which death occurred where urine is not available.
Article: Vitreous alcohol: the author's replyForensic Science International 05/1995; 73(2):159-160. DOI:10.1016/0379-0738(95)93910-E · 2.12 Impact Factor
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ABSTRACT: Vitreous humour alcohol concentration (VHAC) and blood alcohol concentration (BAC) measured by gas chromatography were available from 345 medico-legal autopsies. Simple linear regression with BAC as outcome variable and VHAC as predictor variable (range 1-705 mg%) gave the regression equation BAC = 3.03 + 0.852 VHAC with 95% prediction interval +/- 0.019 square root of [7157272 + (VHAC - 189.7)2] and 99% prediction interval +/- 0.025 square root of [7157272 + (VHAC - 189.7)2]. The residual standard deviation of VHAC was 26 mg%, the standard error of the slope 0.0098 and the 95% confidence interval for the slope 0.833-0.871. In practice a BAC of 80 mg% is predicted with 95% certainty by a VHAC of 150 mg% and similarly a BAC of 150 mg% by a VHAC of 232 mg%. The prediction interval is too wide to be of real practical use. Previous authors have provided various formulae, including a simple conversion factor, to predict BAC from VHAC without taking into account the uncertainty of the prediction for an individual subject. A re-analysis of the raw data from previous publications gave in most instances regression equations significantly different from the authors' own.Forensic Science International 04/1994; 65(2):73-80. DOI:10.1016/0379-0738(94)90262-3 · 2.12 Impact Factor
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ABSTRACT: There were 285 autopsy cases in 2010 where ethanol was the only toxin. To try to ascertain the toxicity of ethanol alone, those cases where clinical details stated 'sudden death', 'collapsed', 'brought in dead to hospital', 'found dead at home', 'fell down stairs and dead at end of stairs', 'sudden death in alcoholic' and 'brought in dead and seizures' were extracted. There were 55 males aged from 23 to 76years and 17 females aged from 41 to 71years who fulfilled these criteria. Blood ethanol ranged from <50 to 556mg/dl. The median band in males is 200-249mg/dl and the 31% of male cases are in the 200smg/dl range, levels conventionally considered benign. The levels found in females were spread relatively evenly across the range 150-600mg/dl. The urine/blood ethanol ratios ranged from 0.13 to 2.02. The blood/vitreous ratios in 10 cases ranged from 0.76 to 1.24 with a median value of 1.16. Calculated blood ethanol from vitreous levels showed a negative bias when compared to the measured value but not in all cases. This limits the role of calculated values in legal cases. The threshold for lethal alcohol toxicity is indistinct and likely to be lower than conventionally acknowledged.Legal Medicine 11/2012; DOI:10.1016/j.legalmed.2012.10.001 · 1.44 Impact Factor